Gene

ptprq

ID
ZDB-GENE-050419-183
Name
protein tyrosine phosphatase receptor type Q
Symbol
ptprq Nomenclature History
Previous Names
  • si:ch211-11f8.3 (1)
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine phosphatase receptor type Q).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from van Eekelen et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ptprq Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 73 Alliance Deafness, autosomal dominant 73 617663
autosomal recessive nonsyndromic deafness 84A Alliance Deafness, autosomal recessive 84A 613391
Associated With ptprq Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR016130 Protein-tyrosine phosphatase, active site
Domain IPR000242 PTP type protein phosphatase
Domain IPR000387 Tyrosine specific protein phosphatases domain
Domain IPR003595 Protein-tyrosine phosphatase, catalytic
Domain IPR003961 Fibronectin type III
Domain IPR041201 PTPRJ, transmembrane domain
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR029021 Protein-tyrosine phosphatase-like
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length Fibronectin type III Fibronectin type III superfamily Immunoglobulin-like fold Protein-tyrosine phosphatase, active site Protein-tyrosine phosphatase, catalytic Protein-tyrosine phosphatase-like PTPRJ, transmembrane domain PTP type protein phosphatase Tyrosine specific protein phosphatases domain
UniProtKB:C7U139 138
UniProtKB:A8DZA4 2301
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations