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ZIRC
ZFIN ID: ZDB-GENE-050419-145
Gene Name: modulator of VRAC current 1
Gene Symbol: mlc1
Sequence Ontology ID : SO:0000704

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Previous Name: si:ch211-192n14.1

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(Including Attributions)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Involved in protein localization to cell surface; localizes to the cell-cell junction; orthologous to human MLC1 (megalencephalic leukoencephalopathy with subcortical cysts 1).
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh328 Point Mutation Unknown Unknown ENU
mlc1_unrecovered Point Mutation Unknown Unknown ENU
sa10246 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13089 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32194 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE
    Data: Fig. 6 from Sirisi et al., 2014
    Observed in:
    DISEASE ASSOCIATED WITH mlc1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    megalencephalic leukoencephalopathy with subcortical cysts 1 Megalencephalic leukoencephalopathy with subcortical cysts 604004
    DISEASE ASSOCIATED WITH mlc1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein localization to cell surface (more)
    Cellular Component cell-cell junction (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR033280 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA mlc1-202 (1) 1177
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM mlc1 No data available
    MARKER RELATIONSHIPS
    mlc1Contained in: [BAC] CH211-170D11 (1) (order this), CH211-192N14 (1) (order this)
    mlc1Encodes: [cDNA] MGC:171761 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001104939 (1) 1413bp
    Genomic GenBank:BX649610 (1) 150831bp
    Select Tool
    Polypeptide UniProtKB:F1QUH3 (1) 392aa
    Sequence Clusters UniGene:119073 (1)
    Sequence Information (all 24)
    ORTHOLOGY for mlc1 (Chr: 18)
    CITATIONS (22)