ZFIN ID: ZDB-GENE-050327-61
Gene Name: sphingomyelin phosphodiesterase acid like 3A
Gene Symbol: smpdl3a    Nomenclature History

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Previous Names: si:ch211-199i15.3, zgc:113352

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have phosphoric diester hydrolase activity. Predicted to be involved in sphingomyelin catabolic process. Predicted to localize to the extracellular space. Orthologous to human SMPDL3A (sphingomyelin phosphodiesterase acid like 3A).
Genome Resources: Alliance (1),  Gene:541525 (1),  Ensembl(GRCz11):ENSDARG00000053119 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14891 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43509 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-smpdl3a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH smpdl3a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH smpdl3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sphingomyelin catabolic process (more)
    Cellular Component extracellular region (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
    Family IPR017064 Acid sphingomyelinase-like phosphodiesterase, predicted
    Homologous_superfamily IPR029052 Metallo-dependent phosphatase-like
    Domain IPR041805 Acid sphingomyelinase/endopolyphosphatase, metallophosphatase domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smpdl3a-201 (1)    Ensembl 1589
    smpdl3a-202 (1)    Ensembl 894
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smpdl3a No data available
    MARKER RELATIONSHIPS
    smpdl3a Contained in: [BAC] CH211-199I15 (1)
    smpdl3a Encodes: [cDNA] MGC:113352 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001014338 (1) 1660 bp
    Genomic GenBank:AL845421 (1) 148289 bp
    Select Tool
    Polypeptide UniProtKB:F1Q7D3 (1) 441 aa
    Sequence Clusters UniGene:91275 (1)
    Sequence Information (all 16)
    ORTHOLOGY for smpdl3a ( Chr: 20 )
    CITATIONS (19)