ZFIN ID: ZDB-GENE-050327-13
Gene Name: ER lipid raft associated 1
Gene Symbol: erlin1    Nomenclature History

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Previous Names: fa10h05, fb19h05, wu:fa10h05, wu:fb19h05, zgc:110547

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have cholesterol binding activity. Predicted to be involved in SREBP signaling pathway. Predicted to localize to endoplasmic reticulum membrane. Is expressed in liver. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 62. Orthologous to human ERLIN1 (ER lipid raft associated 1).
Genome Resources: Alliance (1),  Gene:541490 (1),  Ensembl(GRCz11):ENSDARG00000021991 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:110547]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7155366]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012323Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH erlin1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 62 Alliance Spastic paraplegia 62 615681
    DISEASE ASSOCIATED WITH erlin1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cholesterol metabolic process (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function lipid binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA erlin1-201 (1)    Ensembl 3706
    erlin1-202 (1)    Ensembl 967
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM erlin1 No data available
    MARKER RELATIONSHIPS
    erlin1 Contained in: [BAC] CH211-223P8 (1)
    erlin1 Encodes: [EST] fa10h05 (1), fb19h05, IMAGE:7155366 (1)
    [cDNA] MGC:110547 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001014303 (1) 2000 nt
    Genomic GenBank:AL929005 (1) 166364 nt
    Select Tool
    Polypeptide UniProtKB:Q58EG2 (1) 342 aa
    Sequence Information (all 17)
    ORTHOLOGY for erlin1 ( Chr: 13 )
    CITATIONS (27)