ZFIN ID: ZDB-GENE-050320-85
Gene Name: dihydrolipoamide branched chain transacylase E2
Gene Symbol: dbt
Sequence Ontology ID : SO:0000704

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Attributions

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Previous Names: im:7147214, que, zgc:103768

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(Including Attributions)
Location: Chr: 22 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have acetyltransferase activity and lipoic acid binding activity; involved in branched-chain amino acid metabolic process; predicted to localize to the mitochondrion; used to study maple  ...
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7147214]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la022191Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ti274 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 7 figures from 3 publications
    Observed in:
    DISEASE ASSOCIATED WITH dbt HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    maple syrup urine disease Maple syrup urine disease, type II 248600
    DISEASE ASSOCIATED WITH dbt VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    maple syrup urine disease dbtti274/ti274 standard conditions Friedrich et al., 2012
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process branched-chain amino acid metabolic process (more)
    Molecular Function transferase activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000089 (1)
  • InterPro:IPR001078 (1)
  • InterPro:IPR003016 (1)
  • InterPro:IPR004167 (1)
  • InterPro:IPR011053 (1)
  • InterPro:IPR015761 (1)
  • InterPro:IPR023213 (1)
  • InterPro:IPR036625 (1)
  • PROSITE:PS00189 (1)
  • PROSITE:PS50968 (1)
  • PROSITE:PS51826 (1)
  • Pfam:PF00198 (1)
  • Pfam:PF00364 (1)
  • Pfam:PF02817 (1)
  • EC:2.3.1.- (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA dbt-002 (1) 502
    mRNA dbt-202 (1) 2374
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM dbt No data available
    MARKER RELATIONSHIPS
    dbtContained in: [BAC] DKEY-168J9 (1) (order this)
    dbtEncodes: [EST] IMAGE:7147214 (1) (order this)
    [cDNA] MGC:103768 (1) (order this), MGC:192702 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001013515 (1) 2320bp
    Genomic GenBank:CR751228 (1) 124694bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4INZ8 (1) 532aa
    Sequence Clusters UniGene:79876 (1)
    Sequence Information (all 16)
    OTHER dbt GENE PAGES
  • Alliance (1)
  • Gene:541388 (1)
  • VEGA:OTTDARG00000016703 (1)
  • ORTHOLOGY for dbt (Chr: 22)
    CITATIONS (25)