ZFIN ID: ZDB-GENE-050320-116
Gene Name: X-ray repair complementing defective repair in Chinese hamster cells 3
Gene Symbol: xrcc3    Nomenclature History

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Previous Names: im:7142103, si:dkey-11b8.1, zgc:101608

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to contribute to crossover junction endodeoxyribonuclease activity and four-way junction DNA binding activity. Predicted to be involved in DNA metabolic process. Predicted to localize to the Rad51C-XRCC3 complex and replication fork. Human ortholog(s) of this gene implicated in breast cancer; familial melanoma; and pancreatic cancer. Orthologous to human XRCC3 (X-ray repair cross complementing 3).
Genome Resources: Alliance (1),  Gene:541414 (1),  Ensembl(GRCz11):ENSDARG00000017928 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:101608]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10430 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-xrcc3
    1
    CRISPR2-xrcc3
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH xrcc3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    breast cancer Alliance {Breast cancer, susceptibility to} 114480
    {Melanoma, cutaneous malignant, 6} 613972
    DISEASE ASSOCIATED WITH xrcc3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA repair (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR013632 DNA recombination and repair protein Rad51-like, C-terminal
    Domain IPR020588 DNA recombination and repair protein RecA-like, ATP-binding domain
    Domain IPR033925 Rad51/DMC1/RadA
    Family IPR016467 DNA recombination and repair protein, RecA-like
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA xrcc3-201 (1)    Ensembl 1672
    xrcc3-202 (1)    Ensembl 777
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM xrcc3 No data available
    MARKER RELATIONSHIPS
    xrcc3 Contained in: [BAC] DKEY-11B8 (1) (order this)
    xrcc3 Encodes: [EST] IMAGE:7142103 (1)
    [cDNA] MGC:101608 (1), MGC:191569 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001013541 (1) 1441 nt
    Genomic GenBank:BX255905 (1) 118677 nt
    Select Tool
    Polypeptide UniProtKB:Q5BL30 (1) 352 aa
    Sequence Information (all 15)
    ORTHOLOGY for xrcc3 ( Chr: 20 )
    CITATIONS (24)