Gene

dnmt3bb.1

ID
ZDB-GENE-050314-1
Name
DNA (cytosine-5-)-methyltransferase 3 beta, duplicate b.1
Symbol
dnmt3bb.1 Nomenclature History
Previous Names
  • cb633 (1)
  • dnmt3b1 (1)
  • dnmt3b (1)
  • dnmt4
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have DNA (cytosine-5-)-methyltransferase activity and metal ion binding activity. Involved in several processes, including DNA methylation on cytosine within a CG sequence; hematopoietic stem cell homeostasis; and regulation of hematopoietic stem cell differentiation. Predicted to localize to nucleus. Is expressed in several structures, including digestive system; hematopoietic system; immature eye; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; autoimmune disease (multiple); carcinoma (multiple); immunodeficiency-centromeric instability-facial anomalies syndrome 1; and thymoma. Orthologous to human DNMT3B (DNA methyltransferase 3 beta).
Genome Resources
Note
None
Expression
All Expression Data
26 figures from 10 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnmt3bb.1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency-centromeric instability-facial anomalies syndrome 1 Alliance Immunodeficiency-centromeric instability-facial anomalies syndrome 1 242860
Associated With dnmt3bb.1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018117 DNA methylase, C-5 cytosine-specific, active site
Domain IPR000313 PWWP domain
Domain IPR025766 ADD domain
Domain IPR030488 DNA (cytosine-5)-methyltransferase 3B, ADD domain
Domain IPR040552 DNMT3, cysteine rich ADD domain
Family IPR001525 C-5 cytosine methyltransferase
Homologous_superfamily IPR011011 Zinc finger, FYVE/PHD-type
Homologous_superfamily IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Domain Details Per Protein
Protein Length ADD domain C-5 cytosine methyltransferase DNA (cytosine-5)-methyltransferase 3B, ADD domain DNA methylase, C-5 cytosine-specific, active site DNMT3, cysteine rich ADD domain PWWP domain S-adenosyl-L-methionine-dependent methyltransferase Zinc finger, FYVE/PHD-type
UniProtKB:A0A2R8QML7 806
UniProtKB:Q588C6 816
UniProtKB:Q08CT6 816
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations