Gene

prkcaa

ID
ZDB-GENE-050208-100
Name
protein kinase C, alpha, a
Symbol
prkcaa Nomenclature History
Previous Names
  • prkca
  • im:7139045 (1)
  • si:dkey-8l19.1 (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Involved in blood coagulation. Predicted to localize to mitochondrial membrane; nucleus; and plasma membrane. Is expressed in EVL; hatching gland; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Williams et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkcaa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Pituitary tumor, invasive
Associated With prkcaa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000008 C2 domain
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain IPR017892 Protein kinase, C-terminal
Domain IPR020454 Diacylglycerol/phorbol-ester binding
Domain IPR034663 Classical Protein Kinase C alpha, catalytic domain
Family IPR014375 Protein kinase C, alpha/beta/gamma types
Family IPR015727 Protein kinase C mu-related
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal C2 domain C2 domain superfamily Classical Protein Kinase C alpha, catalytic domain Diacylglycerol/phorbol-ester binding Protein kinase, ATP binding site Protein kinase C, alpha/beta/gamma types Protein kinase C-like, phorbol ester/diacylglycerol-binding domain Protein kinase C mu-related Protein kinase, C-terminal Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:A0A2R8QIY5 670
UniProtKB:Q6AXM3 210
UniProtKB:F1R444 634
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-prkca polyclonal IgG Rabbit
  • IHC
Santa Cruz Biotechnology, Inc.
6
Ab1-prkca polyclonal IgG Rabbit
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
22
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations