ZFIN ID: ZDB-GENE-050208-100
Gene Name: protein kinase C, alpha, a
Gene Symbol: prkcaa    Nomenclature History

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Previous Names: prkca, im:7139045 (1), si:dkey-8l19.1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in blood coagulation. Is expressed in EVL; hatching gland; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; large cell carcinoma; malignant glioma (multiple); and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha).
Genome Resources: Alliance (1),  Gene:497384 (1),  Ensembl(GRCz11):ENSDARG00000115657 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct7aGt Transgenic Insertion Intron 3 Unknown DNA
la015857Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-prkcaa N/A 1
    MO2-prkcaa N/A 1
    MO3-prkcaa N/A 1
    DISEASE ASSOCIATED WITH prkcaa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Pituitary tumor, invasive
    DISEASE ASSOCIATED WITH prkcaa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood coagulation (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prkca-001 (1)    Ensembl 2172
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-prkca polyclonal IgG Rabbit IHC Santa Cruz Biotechnology, Inc.
    6
    Ab1-prkca polyclonal IgG Rabbit IHC, WB Santa Cruz Biotechnology, Inc.
    22
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prkcaa No data available
    MARKER RELATIONSHIPS
    prkcaa Contained in: [BAC] CH211-152N14 (1), DKEY-8L19 (1) (order this)
    prkcaa Encodes: [EST] IMAGE:7139045 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001256241 (1) 2172 nt
    Genomic RefSeq:NW_018394634 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QIY5 (1) 670 aa
    Sequence Information (all 16)
    ORTHOLOGY for prkcaa ( Chr: 6 )
    CITATIONS (39)