ZFIN ID: ZDB-GENE-050127-1
Gene Name: glial cells missing transcription factor 2
Gene Symbol: gcm2    Nomenclature History

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Previous Names: Gcm-2 (1), gcmb (1), mero, merovingian

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in animal organ development; epidermal cell fate specification; and metal ion homeostasis. Predicted to localize to nucleus. Is expressed in several structures, including ectoderm; head; macrophage; pharynx; and yolk. Human ortholog(s) of this gene implicated in familial isolated hypoparathyroidism and hyperparathyroidism. Orthologous to human GCM2 (glial cells missing transcription factor 2).
Genome Resources: Alliance (1),  Gene:449615 (1),  Ensembl(GRCz11):ENSDARG00000045413 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37826 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • w40 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gcm2 N/A 1
    MO2-gcm2 N/A 1
    MO3-gcm2 N/A 1
    MO4-gcm2 N/A 2
    MO5-gcm2 N/A 12
    DISEASE ASSOCIATED WITH gcm2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hyperparathyroidism 4 617343
    Hypoparathyroidism, familial isolated 2 618883
    DISEASE ASSOCIATED WITH gcm2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process animal organ morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gcm2-201 (1)    Ensembl 2099
    gcm2-202 (1)    Ensembl 2031
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gcm2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:gcm2-EGFP) hsp70l EGFPgcm2 Danio rerio 1 2
    MARKER RELATIONSHIPS
    gcm2 Contained in: [BAC] CH211-203G10 (1)
    gcm2 Contains: [STS] unp1185 (1)
    gcm2 Encodes: [cDNA] MGC:193909 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001005603 (1) 2035 nt
    Genomic GenBank:BX546453 (1) 160383 nt
    Select Tool
    Polypeptide UniProtKB:Q2KT54 (1) 496 aa
    Sequence Information (all 21)
    ORTHOLOGY for gcm2 ( Chr: 24 )
    CITATIONS (49)