ZFIN ID: ZDB-GENE-041213-1
Gene Name: unc-5 netrin receptor B
Gene Symbol: unc5b    Nomenclature History

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Previous Name: sb:eu495

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have netrin receptor activity. Involved in branching involved in blood vessel morphogenesis and negative regulation of angiogenesis. Predicted to localize to integral component of membrane. Is expressed in several structures, including immature eye; nervous system; neural keel; pectoral fin bud; and trunk vasculature. Orthologous to human UNC5B (unc-5 netrin receptor B).
Genome Resources: Alliance (1),  Gene:494130 (1),  Ensembl(GRCz11):ENSDARG00000033327 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la012343Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018521Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018522Tg Transgenic Insertion Unknown Unknown DNA
    la018523Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018524Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la027428Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9232 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13358 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35510 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-unc5b N/A 3
    MO2-unc5b N/A 2
    DISEASE ASSOCIATED WITH unc5b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH unc5b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel morphogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA unc5b-201 (1)    Ensembl 2735
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-unc5b monoclonal IgG1 , k Mouse 1
    Ab2-unc5b monoclonal IgG1 , k Mouse IHC 1
    CONSTRUCTS WITH SEQUENCES FROM unc5b No data available
    MARKER RELATIONSHIPS
    unc5b Contained in: [BAC] CH211-39I13 (1)
    unc5b Encodes: [EST] eu495 (1)
    [cDNA] cssl:d832 (1), MGC:195017 (1), MGC:195041 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001111149 (1) 3400 nt
    Genomic GenBank:CR456683 (1) 166196 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IE04 (1) 940 aa
    Sequence Information (all 34)
    ORTHOLOGY for unc5b ( Chr: 13 )
    CITATIONS (47)