ZFIN ID: ZDB-GENE-041011-3
Gene Name: protein phosphatase 1, regulatory subunit 12A
Gene Symbol: ppp1r12a    Nomenclature History

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Previous Names: mypt1 (1), myosin phosphatase targeting subunit 1 (1), myosin-binding subunit of myosin phosphatase (1), si:dkey-28j4.1 (1), unm p82emcf, unm_p82emcf, zgc:110448 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity. Involved in several processes, including actin filament bundle organization; convergent extension involved in axis elongation; and nervous system development. Predicted to localize to A band; PTW/PP1 phosphatase complex; and Z disc. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and myotome. Orthologous to several human genes including PPP1R12A (protein phosphatase 1 regulatory subunit 12A).
Genome Resources: Alliance (1),  Gene:445393 (1),  Ensembl(GRCz11):ENSDARG00000010784 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi2653Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la024489Tg Transgenic Insertion Unknown Unknown DNA
    la024490Tg Transgenic Insertion Unknown Unknown DNA
    la024491Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • p82emcf Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15933 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20271 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20272 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25279 Point Mutation Unknown Premature Stop ENU
    sq181 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ppp1r12a
    1
    CRISPR2-ppp1r12a
    1
    CRISPR3-ppp1r12a
    1
    CRISPR4-ppp1r12a
    1
    CRISPR5-ppp1r12a
    1
    MO1-ppp1r12a N/A 1
    MO2-ppp1r12a N/A 4
    MO3-ppp1r12a N/A 4
    PHENOTYPE
    Data: 25 figures from 9 publications
    Observed in:
    DISEASE ASSOCIATED WITH ppp1r12a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Genitourinary and/or/brain malformation syndrome 618820
    DISEASE ASSOCIATED WITH ppp1r12a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in axis elongation (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ppp1r12a-201 (1)    Ensembl 4846
    ppp1r12a-tv201 (1) 3313
    ppp1r12a-tv202 (1) 3032
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ppp1r12a No data available
    MARKER RELATIONSHIPS
    ppp1r12a Contained in: [BAC] DKEY-28J4 (1) (order this)
    ppp1r12a Encodes: [cDNA] MGC:110448 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001003870 (1) 3322 nt
    Genomic GenBank:BX537286 (1) 179930 nt
    Select Tool
    Polypeptide UniProtKB:Z4YIS0 (1) 1117 aa
    Sequence Information (all 25)
    ORTHOLOGY for ppp1r12a ( Chr: 4 )
    CITATIONS (55)