ZFIN Gene: ppp1r12a

ZFIN ID: ZDB-GENE-041011-3

ZFIN ID: ZDB-GENE-041011-3

Gene Name:

protein phosphatase 1, regulatory subunit 12A

Gene Symbol:

ppp1r12a

Sequence Ontology ID :

Previous Names:

mypt1 (1), myosin phosphatase targeting subunit 1 (1), myosin-binding subunit of myosin phosphatase (1), si:dkey-28j4.1 (1), unm p82emcf, unm_p82emcf, zgc:110448 (1)

Location:

Chr: 4 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Exhibits protein heterodimerization activity. Involved in several processes, including actin filament bundle organization; convergent extension involved in axis elongation; and nervous system ...

GENE EXPRESSION
All Expression Data:	2 figures from 2 publications
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
	brain endoderm endodermal cell gut head hepatocyte mesoderm myotome somite spinal cord whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hi2653Tg	Transgenic Insertion	Intron 1	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
la024489Tg	Transgenic Insertion	Unknown	Unknown	DNA
la024490Tg	Transgenic Insertion	Unknown	Unknown	DNA
la024491Tg	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
p82emcf	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa15933	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20271	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa20272	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa25279	Point Mutation	Unknown	Premature Stop	ENU
sq181	Point Mutation	Unknown	Unknown	ENU

Targeting reagents:

PHENOTYPE

Data:

24 figures from 8 publications

Observed in:

DISEASE ASSOCIATED WITH ppp1r12a HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH ppp1r12a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	convergent extension involved in axis elongation (more)
Cellular Component	A band (more)
Molecular Function	protein heterodimerization activity (more)

GO Terms (all 20)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR002110 (1) InterPro:IPR017401 (1) InterPro:IPR020683 (1) InterPro:IPR031775 (1) InterPro:IPR036770 (1)	PROSITE:PS50088 (1) PROSITE:PS50297 (1)	Pfam:PF12796 (1) Pfam:PF15898 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	ppp1r12a-201 (1)	4846	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM ppp1r12a No data available

MARKER RELATIONSHIPS

ppp1r12aContained in:	[BAC] DKEY-28J4 (1) (order this)
ppp1r12aEncodes:	[cDNA] MGC:110448 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001003870 (1)	3322bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX537286 (1)	179930bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Z4YIS0 (1)	1117aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:133094 (1)

Sequence Information (all 26)

OTHER ppp1r12a GENE PAGES

Alliance (1)

Gene:445393 (1)

VEGA:OTTDARG00000008393 (1)

Ensembl(GRCz11):ENSDARG00000010784 (2)

ORTHOLOGY for ppp1r12a (Chr: 4)

CITATIONS (52)

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