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Gene

ppp1r12a

ID
ZDB-GENE-041011-3
Name
protein phosphatase 1, regulatory subunit 12A
Symbol
ppp1r12a Nomenclature History
Previous Names
  • mypt1 (1)
  • myosin phosphatase targeting subunit 1 (1)
  • myosin-binding subunit of myosin phosphatase (1)
  • si:dkey-28j4.1 (1)
  • unm p82emcf
  • unm_p82emcf
  • zgc:110448 (1)
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Enables protein heterodimerization activity. Acts upstream of or within several processes, including actin filament bundle organization; convergent extension involved in axis elongation; and nervous system development. Located in cytoplasm. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and myotome. Orthologous to several human genes including PPP1R12A (protein phosphatase 1 regulatory subunit 12A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
32 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ppp1r12a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Genitourinary and/or/brain malformation syndrome 618820
Associated With ppp1r12a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR020683 Ankyrin repeat-containing domain
Domain IPR031775 cGMP-dependent protein kinase, interacting domain
Family IPR017401 Protein phosphatase 1 regulatory subunit 12A/B/C
Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
Repeat IPR002110 Ankyrin repeat
Domain Details Per Protein
Protein Length Ankyrin repeat Ankyrin repeat-containing domain Ankyrin repeat-containing domain superfamily cGMP-dependent protein kinase, interacting domain Protein phosphatase 1 regulatory subunit 12A/B/C
UniProtKB:Q6DRG7 1049
UniProtKB:Z4YIS0 1117
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations