| ZFIN ID: ZDB-GENE-041011-3 |
| Gene Name: | protein phosphatase 1, regulatory subunit 12A | |||||||||||||
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| Gene Symbol: | ppp1r12a Nomenclature History |
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Attributions
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| Previous Names: | mypt1 (1), myosin phosphatase targeting subunit 1 (1), myosin-binding subunit of myosin phosphatase (1), si:dkey-28j4.1 (1), unm p82emcf, unm_p82emcf, zgc:110448 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 4 Mapping Details/Browsers | |||||||||||||
| Description: | Exhibits protein heterodimerization activity. Involved in several processes, including actin filament bundle organization; convergent extension involved in axis elongation; and nervous system development. Predicted to localize to A band; PTW/PP1 phosphatase complex; and Z disc. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and myotome. Orthologous to several human genes including PPP1R12A (protein phosphatase 1 regulatory subunit 12A). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:445393 (1), Ensembl(GRCz11):ENSDARG00000010784 (2) | |||||||||||||
| All Expression Data: | 3 figures from 3 publications |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) |
| High Throughput Expression: | GEO (1) Expression Atlas (1) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| CRISPR1-ppp1r12a |
|
1 |
| CRISPR2-ppp1r12a |
|
1 |
| CRISPR3-ppp1r12a |
|
1 |
| CRISPR4-ppp1r12a |
|
1 |
| CRISPR5-ppp1r12a |
|
1 |
| MO1-ppp1r12a | N/A | 1 |
| MO2-ppp1r12a | N/A | 4 |
| MO3-ppp1r12a | N/A | 4 |
PHENOTYPE
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Genitourinary and/or/brain malformation syndrome | 618820 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | convergent extension involved in axis elongation (more) |
| Cellular Component | cytoplasm (more) |
| Molecular Function | protein heterodimerization activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
ppp1r12a-201
(1)
|
4846 |
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|
|
| ppp1r12a-tv201 (1) | 3313 |
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| ppp1r12a-tv202 (1) | 3032 |
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM ppp1r12a
No data available
MARKER RELATIONSHIPS
| ppp1r12a Contained in: | [BAC] DKEY-28J4 (1) (order this) |
| ppp1r12a Encodes: | [cDNA] MGC:110448 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001003870 (1) | 3322 nt |
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| Genomic | GenBank:BX537286 (1) | 179930 nt | |
| Polypeptide | UniProtKB:Z4YIS0 (1) | 1117 aa |
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ORTHOLOGY for ppp1r12a (
Chr:
4
)
CITATIONS (55)