ZFIN ID: ZDB-GENE-041010-207
Gene Name: galactosidase, alpha
Gene Symbol: gla    Nomenclature History

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Previous Name: zgc:101584

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have alpha-galactosidase activity. Predicted to be involved in glycoside catabolic process; glycosylceramide catabolic process; and oligosaccharide metabolic process. Predicted to localize to cytoplasm. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha).
Genome Resources: Alliance (1),  Gene:450083 (1),  Ensembl(GRCz11):ENSDARG00000036155 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:101584]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa684 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gla HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Fabry disease Alliance Fabry disease 301500
    Fabry disease, cardiac variant 301500
    DISEASE ASSOCIATED WITH gla VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process carbohydrate metabolic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gla-201 (1)    Ensembl 1483
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gla No data available
    MARKER RELATIONSHIPS
    gla Contained in: [BAC] CH211-127L12, CH211-229H7
    gla Encodes: [cDNA] MGC:101584 (1), MGC:191930 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001006103 (1) 1496 nt
    Genomic GenBank:BX005218 (1) 183670 nt
    Select Tool
    Polypeptide UniProtKB:F1Q5G5 (1) 409 aa
    Sequence Information (all 15)
    ORTHOLOGY for gla ( Chr: 14 )
    CITATIONS (18)