ZFIN ID: ZDB-GENE-040912-3
Gene Name: aldehyde dehydrogenase 8 family, member A1
Gene Symbol: aldh8a1    Nomenclature History

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Attributions

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Previous Names: Raldh4 (1), fi34g05, wu:fi34g05 (1), zgc:92068

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have aminomuconate-semialdehyde dehydrogenase activity. Involved in liver development. Predicted to localize to the cytoplasm. Is expressed in intestinal bulb; intestinal bulb epithelium; intestine; and liver. Orthologous to human ALDH8A1 (aldehyde dehydrogenase 8 family member A1).
Genome Resources: Alliance (1),  Gene:447801 (1),  Ensembl(GRCz11):ENSDARG00000036776 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92068]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3225 Point Mutation Unknown Premature Stop ENU
sa44022 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-aldh8a1 N/A 1
    MO2-aldh8a1 N/A 1
    PHENOTYPE
    Data: Fig. 2 from Garnaas et al., 2012
    Observed in:
    DISEASE ASSOCIATED WITH aldh8a1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH aldh8a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process liver development (more)
    Cellular Component cytoplasm (more)
    Molecular Function aminomuconate-semialdehyde dehydrogenase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR015590 Aldehyde dehydrogenase domain
    Conserved_site IPR016160 Aldehyde dehydrogenase, cysteine active site
    Homologous_superfamily IPR016161 Aldehyde/histidinol dehydrogenase
    Homologous_superfamily IPR016162 Aldehyde dehydrogenase, N-terminal
    Homologous_superfamily IPR016163 Aldehyde dehydrogenase, C-terminal
    Conserved_site IPR029510 Aldehyde dehydrogenase, glutamic acid active site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA aldh8a1-201 (1)    Ensembl 1690
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM aldh8a1 No data available
    MARKER RELATIONSHIPS
    aldh8a1 Contained in: [BAC] DKEY-161P7 (1) (order this)
    aldh8a1 Encodes: [EST] fi34g05
    [cDNA] MGC:92068 (1), MGC:173794 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001004540 (1) 1673 bp
    Genomic RefSeq:NW_018395160 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QNV6 (1) 487 aa
    Sequence Clusters UniGene:16380 (1)
    Sequence Information (all 23)
    ORTHOLOGY for aldh8a1 ( Chr: 23 )
    CITATIONS (33)