ZFIN ID: ZDB-GENE-040819-2
Gene Name: myosin VIa
Gene Symbol: myo6a    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Involved in angioblast cell migration from lateral mesoderm to midline and artery morphogenesis. Predicted to localize to several cellular components, including actin cytoskeleton; endocytic vesicle; and ruffle. Is expressed in dorsal aorta; neural tube; posterior cardinal vein; and somite. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI).
Genome Resources: Alliance (1),  Gene:445473 (1),  Ensembl(GRCz11):ENSDARG00000044016 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa3048 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6610 Point Mutation Unknown Premature Stop ENU
    sa16041 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23617 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43364 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-myo6a
    3
    CRISPR2-myo6a
    2
    MO1-myo6a N/A 1
    MO2-myo6a N/A 1
    DISEASE ASSOCIATED WITH myo6a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 22 Alliance Deafness, autosomal dominant 22 606346
    Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy 606346
    autosomal recessive nonsyndromic deafness 37 Alliance Deafness, autosomal recessive 37 607821
    DISEASE ASSOCIATED WITH myo6a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process angioblast cell migration from lateral mesoderm to midline (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myo6a-202 (1)    Ensembl 5010
    myo6a-203 (1)    Ensembl 4988
    myo6a-205 (1)    Ensembl 542
    ncRNA myo6a-003 (1)    Ensembl 536
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myo6a No data available
    MARKER RELATIONSHIPS
    myo6a Contained in: [BAC] CH73-316K11 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004111 (1) 5022 nt
    Genomic GenBank:CU469066 (1) 95331 nt
    Select Tool
    Polypeptide UniProtKB:Q68RJ2 (1) 1292 aa
    Sequence Information (all 29)
    ORTHOLOGY for myo6a ( Chr: 20 )
    CITATIONS (27)