Gene

myo6a

ID
ZDB-GENE-040819-2
Name
myosin VIa
Symbol
myo6a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity; actin-dependent ATPase activity; and microfilament motor activity. Involved in angioblast cell migration from lateral mesoderm to midline and artery morphogenesis. Predicted to localize to several cellular components, including endocytic vesicle; microvillus; and ruffle. Is expressed in dorsal aorta; neural tube; posterior cardinal vein; and somite. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Orthologous to human MYO6 (myosin VI).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Lanahan et al., 2010
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With myo6a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 22 Alliance Deafness, autosomal dominant 22 606346
autosomal dominant nonsyndromic deafness 22 Alliance Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy 606346
autosomal recessive nonsyndromic deafness 37 Alliance Deafness, autosomal recessive 37 607821
Associated With myo6a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR001609 Myosin head, motor domain
Domain IPR004009 Myosin, N-terminal, SH3-like
Domain IPR032412 Myosin VI, cargo binding domain
Domain IPR036114 Class VI myosin, motor domain
Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036961 Kinesin motor domain superfamily
Domain Details Per Protein
Protein Length Class VI myosin, motor domain IQ motif, EF-hand binding site Kinesin motor domain superfamily Myosin head, motor domain Myosin, N-terminal, SH3-like Myosin S1 fragment, N-terminal Myosin VI, cargo binding domain P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1Q6Q6 1253
UniProtKB:E9QCU8 1288
UniProtKB:Q68RJ2 1292
UniProtKB:Q6B334 1253
UniProtKB:R4GDY7 181
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations