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ZIRC
ZFIN ID: ZDB-GENE-040801-41
Gene Name: major intrinsic protein of lens fiber a
Gene Symbol: mipa    Nomenclature History

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Previous Names: mip1, aqp0a (1), zgc:100858

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits water channel activity. Involved in lens development in camera-type eye and water transport. Predicted to localize to the integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in cataract; cataract 15 multiple types; and nephrogenic diabetes insipidus. Is expressed in eye; lens; lens fiber cell; and solid lens vesicle. Orthologous to several human genes including MIP (major intrinsic protein of lens fiber).
Genome Resources: Alliance (1),  Gene:445140 (1),  Ensembl(GRCz11):ENSDARG00000037285 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ir1090 Small Deletion Unknown Unknown CRISPR
sa32445 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-mipa 1
    CRISPR2-mipa
    2
    MO1-mipa N/A 3
    DISEASE ASSOCIATED WITH mipa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cataract 15 multiple types Alliance Cataract 15, multiple types 615274
    DISEASE ASSOCIATED WITH mipa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process water transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function water channel activity (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mipa-201 (1)    Ensembl 2844
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mipa polyclonal Rabbit IHC, WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mipa No data available
    MARKER RELATIONSHIPS
    mipa Contained in: [BAC] DKEY-157G16 (1) (order this)
    mipa Encodes: [cDNA] MGC:100858 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001003534 (1) 2905 bp
    Genomic GenBank:CR354433 (1) 205769 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q6DEI6 (1) 263 aa
    Sequence Clusters UniGene:90943 (1)
    Sequence Information (all 11)
    ORTHOLOGY for mipa ( Chr: 23 )
    CITATIONS (30)