ZFIN ID: ZDB-GENE-040724-82
Gene Name: mediator complex subunit 23
Gene Symbol: med23    Nomenclature History

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Previous Names: crsp3, si:ch211-272f15.2 (1), zgc:91979 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Involved in cardiovascular system development; negative regulation of neurogenesis; and pigmentation. Predicted to localize to mediator complex and transcription regulator complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MED23 (mediator complex subunit 23).
Genome Resources: Alliance (1),  Gene:445483 (1),  Ensembl(GRCz11):ENSDARG00000029157 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: Expression Atlas (1)
DISEASE ASSOCIATED WITH med23 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive non-syndromic intellectual disability Alliance Mental retardation, autosomal recessive 18 614249
DISEASE ASSOCIATED WITH med23 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process circulatory system development (more)
Cellular Component nucleus (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA med23-201 (1)    Ensembl 4289
med23-202 (1)    Ensembl 4645
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-med23 monoclonal IgG1 , k Mouse WB BD Biosciences
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM med23 No data available
MARKER RELATIONSHIPS
med23 Contained in: [BAC] CH211-272F15
med23 Encodes: [cDNA] MGC:91979 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001003990 (1) 4668 nt
Genomic GenBank:BX072559 (1) 156196 nt
Select Tool
Polypeptide UniProtKB:B8A4G4 (1) 1387 aa
Sequence Information (all 17)
ORTHOLOGY for med23 ( Chr: 20 )
CITATIONS (23)