ZFIN Gene: pak4

ZFIN ID: ZDB-GENE-040704-69

ZFIN ID: ZDB-GENE-040704-69

Gene Name:

p21 protein (Cdc42/Rac)-activated kinase 4

Gene Symbol:

pak4 Nomenclature History

Previous Names:

im:5916170, wu:fd12b01, zgc:92014 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 15 Mapping Details/Browsers

Description:

Predicted to have protein serine/threonine kinase activity. Involved in embryonic morphogenesis and myeloid leukocyte differentiation. Predicted to localize to cytoplasm. Is expressed in post-vent region. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4).

Genome Resources:

Alliance (1), Gene:431769 (1), Ensembl(GRCz11):ENSDARG00000018110 (2)

GENE EXPRESSION
All Expression Data:	Fig. 1 from Law et al., 2013
Wild-type Stages, Structures:	Cleavage:8-cell (1.25h-1.5h) to Pharyngula:Prim-5 (24.0h-30.0h)
	post-vent region somite whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
y276	Small Deletion	Unknown	Frameshift	TALEN
y277	Small Deletion	Exon 2	Frameshift	TALEN

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-pak4	N/A	1
MO2-pak4	N/A	1
MO3-pak4	N/A	2
MO4-pak4	N/A	2
MO5-pak4	N/A	2
TALEN1-pak4	y276 y277	1

PHENOTYPE

Data:	5 figures from 2 publications
Observed in:	blood blood circulation cranial cartilage cranial vasculature embryonic morphogenesis eye head intersegmental vein myeloid cell differentiation myeloid leukocyte pericardium somite trunk vasculature whole organism anterior-posterior axis

DISEASE ASSOCIATED WITH pak4 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH pak4 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	embryonic morphogenesis (more)
Cellular Component	cytoplasm (more)
Molecular Function	ATP binding (more)

GO Terms (all 14)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	pak4-201 (1)	5449	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-pak4			Rabbit	WB		2

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM pak4 No data available

MARKER RELATIONSHIPS

pak4 Contained in:	[BAC] DKEY-54N8 (1) (order this)
pak4 Encodes:	[EST] fd12b01 (1), IMAGE:5916170 [cDNA] MGC:92014 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001002222 (1)	5447 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU856359 (1)	216188 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:F1QZR2 (1)	664 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 14)

ORTHOLOGY for pak4 ( Chr: 15 )

CITATIONS (25)

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