ZFIN ID: ZDB-GENE-040625-35
Gene Name: actin, alpha, cardiac muscle 2
Gene Symbol: actc2    Nomenclature History

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Previous Name: zgc:86709 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have ATP binding activity. Predicted to be involved in mesenchyme migration and positive regulation of gene expression. Predicted to localize to several cellular components, including cell body; filopodium; and lamellipodium. Is expressed in heart tube and post-vent region. Human ortholog(s) of this gene implicated in atrial heart septal defect 5; dilated cardiomyopathy; dilated cardiomyopathy 1R; and hypertrophic cardiomyopathy 11. Orthologous to human ACTC1 (actin alpha cardiac muscle 1).
Genome Resources: Alliance (1),  Gene:570210 (1),  Ensembl(GRCz11):ENSDARG00000057911 (1)
Note: The nomenclature for this gene was based on evidence from Witjes et al. (2019) and in collaboration with HGNC and MGI.
GENE EXPRESSION
All Expression Data: 2 figures from Ojehomon et al., 2018
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH actc2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH actc2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process mesenchyme migration (more)
Cellular Component cell body (more)
Molecular Function ATP binding (more)
GO Terms (all 11)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA actc1-201 (1)    Ensembl 1570
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM actc2 No data available
MARKER RELATIONSHIPS
actc2 Contained in: [BAC] CH211-260D9 (1), RP71-1C22 (1)
actc2 Encodes: [cDNA] MGC:86709 (1), MGC:174767 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001002066 (1) 1436 nt
Genomic GenBank:AL645822 (1) 181112 nt
Select Tool
Polypeptide UniProtKB:Q6IQL9 (1) 377 aa
Sequence Information (all 14)
ORTHOLOGY for actc2 ( Chr: 20 )
CITATIONS (19)