ZFIN ID: ZDB-PUB-180622-12
Identification of the actc1c cardiac actin gene in zebrafish
Ojehomon, M., Alderman, S.L., Sandhu, L., Sutcliffe, S., Van Raay, T., Gillis, T.E., Dawson, J.F.
Date: 2018
Source: Progress in Biophysics and Molecular Biology   138: 32-37 (Journal)
Registered Authors:
Keywords: actin orthologs, actin protein, in situ hybridization, sequence conservation, zebrafish
MeSH Terms:
  • Actins/chemistry
  • Actins/genetics*
  • Actins/metabolism
  • Amino Acid Sequence
  • Animals
  • Humans
  • Myocardium/metabolism*
  • Zebrafish/genetics*
PubMed: 29913180 Full text @ Prog. Biophys. Mol. Biol.
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ABSTRACT
Zebrafish is rapidly becoming a key model organism for studying a variety of biological processes from molecules to organisms. Interactions involving actin, a contractile protein and part of the cytoskeleton, are regulated by actin binding proteins in the majority of physiological processes in eukaryotic cells. To understand the contribution of actin proteins to the physiological processes of zebrafish, it is important to identify the diverse isoforms of actin encoded by its genome; however, significant sequence identity complicates isoform assignments. Through a combination of human-directed sequence and functional analysis, we have assigned and performed localization of actc1c, a previously undesignated cardiac actin gene, and propose an updated assignment of α-actin protein isoform identities in zebrafish.
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