ZFIN ID: ZDB-GENE-040428-1
Gene Name: retinoblastoma 1
Gene Symbol: rb1

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Previous Names: spc, zgc:154147

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
  retina, whole organism
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
te226a Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty85d Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: TALEN1-rb1 (1)
    PHENOTYPE
    Data: 10 figures from 3 publications
    Observed in: cranial nerve II, exit from mitosis, innervation, larval locomotory behavior (all 14) expand
    DISEASE ASSOCIATED WITH rb1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    lung small cell carcinoma Small cell cancer of the lung, somatic 182280
    osteosarcoma Osteosarcoma, somatic 259500
    retinoblastoma Retinoblastoma 180200
    Retinoblastoma, trilateral 180200
    trilateral retinoblastoma Retinoblastoma 180200
    Retinoblastoma, trilateral 180200
    urinary bladder cancer Bladder cancer, somatic 109800
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process optic nerve development (more)
    Cellular Component Rb-E2F complex (more)
    Molecular Function transcription factor binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002719 (1)
  • InterPro:IPR002720 (1)
  • InterPro:IPR013763 (1)
  • InterPro:IPR015030 (1)
  • InterPro:IPR024599 (1)
  • InterPro:IPR028309 (1)
  • InterPro:IPR033057 (1)
  • Pfam:PF01857 (1)
  • Pfam:PF01858 (1)
  • Pfam:PF08934 (1)
  • Pfam:PF11934 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA rb1-001 (1) 3746
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM rb1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    rb1Contained in: [BAC] CH73-285B21 (1) (order this), DKEYP-14B8 (1)
    rb1Encodes: [cDNA] MGC:154147 (1) (order this), MGC:173456 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077780 (1) 3556bp
    Genomic GenBank:BX296544 (1) 168838bp
    Select Tool
    Polypeptide UniProtKB:A0JMQ4 (1) 903aa
    Sequence Clusters UniGene:42121 (1)
    Sequence Information (all 20)
    OTHER rb1 GENE PAGES
  • Gene:777733 (1)
  • VEGA:OTTDARG00000021029 (1)
  • Ensembl(GRCz10):ENSDARG00000006782 (1)
  • ORTHOLOGY for rb1 (Chr: 21)
    CITATIONS (22)