Gene

rb1

ID
ZDB-GENE-040428-1
Name
retinoblastoma 1
Symbol
rb1 Nomenclature History
Previous Names
  • spc
  • zgc:154147
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have RNA polymerase II activating transcription factor binding activity and RNA polymerase II regulatory region DNA binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nervous system development; and visual perception. Predicted to localize to Rb-E2F complex and chromatin. Used to study cancer. Human ortholog(s) of this gene implicated in nervous system cancer (multiple); osteosarcoma; prostate cancer; small cell carcinoma; and urinary bladder cancer. Is expressed in oocyte stage I; retina; and testis. Orthologous to human RB1 (RB transcriptional corepressor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
5 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
24 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rb1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lung small cell carcinoma Alliance Small cell cancer of the lung, somatic 182280
osteosarcoma Alliance Osteosarcoma, somatic 259500
retinoblastoma Alliance Retinoblastoma 180200
retinoblastoma Alliance Retinoblastoma, trilateral 180200
urinary bladder cancer Alliance Bladder cancer, somatic 109800
Associated With rb1 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002719 Retinoblastoma-associated protein, B-box
Domain IPR002720 Retinoblastoma-associated protein, A-box
Domain IPR013763 Cyclin-like
Domain IPR015030 Retinoblastoma-associated protein, C-terminal
Domain IPR024599 Retinoblastoma-associated protein, N-terminal
Family IPR028309 Retinoblastoma protein family
Homologous_superfamily IPR036915 Cyclin-like superfamily
Domain Details Per Protein
Protein Length Cyclin-like Cyclin-like superfamily Retinoblastoma-associated protein, A-box Retinoblastoma-associated protein, B-box Retinoblastoma-associated protein, C-terminal Retinoblastoma-associated protein, N-terminal Retinoblastoma protein family
UniProtKB:A8WGI9 903
UniProtKB:A0JMQ4 903
UniProtKB:F1Q9D6 903
UniProtKB:Q8JG55 314
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab4-rb1 polyclonal Rabbit
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations