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ZIRC
ZFIN ID: ZDB-GENE-040428-1
Gene Name: retinoblastoma 1
Gene Symbol: rb1    Nomenclature History

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Previous Names: spc, zgc:154147

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II activating transcription factor binding activity and RNA polymerase II regulatory region DNA binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nervous system development; and visual perception. Predicted to colocalize with the nucleus. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including malignant glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Is expressed in retina. Orthologous to human RB1 (RB transcriptional corepressor 1).
Genome Resources: Alliance (1),  Gene:777733 (1),  Ensembl(GRCz11):ENSDARG00000006782 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
is54 Small Deletion Unknown Unknown TALEN
sm11 Small Deletion Exon 2 Frameshift TALEN
te226a Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty85d Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zk3 Small Deletion Exon 1 Frameshift TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-rb1
    1
    CRISPR2-rb1
    1
    TALEN1-rb1
    1
    TALEN2-rb1 2
    TALEN3-rb1
    1
    TALEN4-rb1 1
    TALEN5-rb1 1
    DISEASE ASSOCIATED WITH rb1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lung small cell carcinoma Alliance Small cell cancer of the lung, somatic 182280
    osteosarcoma Alliance Osteosarcoma, somatic 259500
    retinoblastoma Alliance Retinoblastoma 180200
    Retinoblastoma, trilateral 180200
    urinary bladder cancer Alliance Bladder cancer, somatic 109800
    DISEASE ASSOCIATED WITH rb1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    cancer WIK + TALEN3-rb1 standard conditions Solin et al., 2015
    WIK + TALEN2-rb1 standard conditions Solin et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process (more)
    Cellular Component nucleus (more)
    Molecular Function transcription factor binding (more)
    GO Terms (all 24)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rb1-201 (1)    Ensembl 3746
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab4-rb1 polyclonal Rabbit WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rb1 No data available
    MARKER RELATIONSHIPS
    rb1 Contained in: [BAC] CH73-285B21 (1) (order this), DKEYP-14B8 (1)
    rb1 Encodes: [cDNA] MGC:154147 (1) (order this), MGC:173456 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077780 (1) 3556 bp
    Genomic GenBank:BX296544 (1) 168838 bp
    Select Tool
    Polypeptide UniProtKB:A0JMQ4 (1) 903 aa
    Sequence Clusters UniGene:42121 (1)
    Sequence Information (all 20)
    ORTHOLOGY for rb1 ( Chr: 21 )
    CITATIONS (37)