ZFIN ID: ZDB-GENE-040428-1
Gene Name: retinoblastoma 1
Gene Symbol: rb1
Sequence Ontology ID : SO:0000704

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Previous Names: spc, zgc:154147

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
is54 Small Deletion Unknown Unknown TALEN
sm11 Small Deletion Exon 2 Frameshift TALEN
te226a Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • ty85d Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zk3 Small Deletion Exon 1 Frameshift TALEN
    Targeting reagents:
    PHENOTYPE
    Data: 20 figures from 6 publications
    Observed in:
    DISEASE ASSOCIATED WITH rb1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    lung small cell carcinoma Small cell cancer of the lung, somatic 182280
    osteosarcoma Osteosarcoma, somatic 259500
    retinoblastoma Retinoblastoma 180200
    Retinoblastoma, trilateral 180200
    urinary bladder cancer Bladder cancer, somatic 109800
    DISEASE ASSOCIATED WITH rb1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    cancer WIK + TALEN3-rb1 standard conditions Solin et al., 2015
    WIK + TALEN2-rb1 standard conditions Solin et al., 2015
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process optic nerve development (more)
    Cellular Component nucleus (more)
    Molecular Function transcription factor binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR002719 (1)
  • InterPro:IPR002720 (1)
  • InterPro:IPR013763 (1)
  • InterPro:IPR015030 (1)
  • InterPro:IPR024599 (1)
  • InterPro:IPR028309 (1)
  • InterPro:IPR033057 (1)
  • InterPro:IPR036915 (1)
  • Pfam:PF01857 (1)
  • Pfam:PF01858 (1)
  • Pfam:PF08934 (1)
  • Pfam:PF11934 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA rb1-001 (1) 3746
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM rb1 No data available
    MARKER RELATIONSHIPS
    rb1Contained in: [BAC] CH73-285B21 (1) (order this), DKEYP-14B8 (1)
    rb1Encodes: [cDNA] MGC:154147 (1) (order this), MGC:173456 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001077780 (1) 3556bp
    Genomic GenBank:BX296544 (1) 168838bp
    Select Tool
    Polypeptide UniProtKB:A0JMQ4 (1) 903aa
    Sequence Clusters UniGene:42121 (1)
    Sequence Information (all 20)
    OTHER rb1 GENE PAGES
  • Alliance (1)
  • Gene:777733 (1)
  • VEGA:OTTDARG00000021029 (1)
  • Ensembl(GRCz11):ENSDARG00000006782 (1)
  • ORTHOLOGY for rb1 (Chr: 21)
    CITATIONS (30)