ZFIN Gene: vldlr

ZFIN ID: ZDB-GENE-040426-803

ZFIN ID: ZDB-GENE-040426-803

Gene Name:

very low density lipoprotein receptor

Gene Symbol:

vldlr

Sequence Ontology ID :

SO:0000704

Previous Names:

lr8 (1), zgc:55792

Location:

Chr: 10 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have calcium ion binding activity and very-low-density lipoprotein particle receptor activity. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene ...

GENE EXPRESSION
All Expression Data:	13 figures from 3 publications
Directly Submitted Expression Data:	6 figures (8 images) from Thisse et al., 2004 [MGC:55792]
Wild-type Stages, Structures:	Gastrula:Bud (10.0h-10.33h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	axis brain central nervous system cerebellum dorsal telencephalon forebrain hindbrain hypothalamus immature eye midbrain ventral region optic tectum periventricular grey zone neuron pronephric duct retinal ganglion cell retinal ganglion cell layer rhombomere 2 rhombomere 3 rhombomere 4 rhombomere 5 rhombomere 6 spinal cord interneuron tegmentum telencephalon
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
ic3030	Insertion	Unknown	Unknown	CRISPR
sa14068	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa17714	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38785	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tud25Gt	Transgenic Insertion	Intron 2	Unknown	DNA	European Zebrafish Resource Center (EZRC) (order this)

Targeting reagents:

CRISPR1-vldlr (1)

PHENOTYPE

Data:	Fig. 6 from Di Donato et al., 2018
Observed in:	retinal ganglion cell neuron projection

DISEASE ASSOCIATED WITH vldlr HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
cerebellar ataxia, mental retardation and dysequlibrium syndrome	Cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1	224050

DISEASE ASSOCIATED WITH vldlr VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Cellular Component	integral component of membrane (more)
Molecular Function	calcium ion binding (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000033 (1) InterPro:IPR000152 (1) InterPro:IPR000742 (1) InterPro:IPR001881 (1) InterPro:IPR002172 (1) InterPro:IPR011042 (1) InterPro:IPR018097 (1) InterPro:IPR023415 (1) InterPro:IPR032931 (1) InterPro:IPR036055 (1)	PROSITE:PS00010 (1) PROSITE:PS01187 (1) PROSITE:PS01209 (1) PROSITE:PS50068 (1) PROSITE:PS51120 (1)	Pfam:PF00057 (1) Pfam:PF00058 (1) Pfam:PF07645 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
ncRNA	vldlr-002 (1)	921	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	vldlr-003 (1)	752	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	vldlr-203 (1)	3496	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM vldlr No data available

MARKER RELATIONSHIPS

vldlrContained in:	[BAC] CH211-241O7 (1) (order this)
vldlrEncodes:	[cDNA] MGC:55792 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_200923 (1)	3751bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR628386 (1)	148044bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7FF13 (1)	866aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:82354 (1)

Sequence Information (all 22)

OTHER vldlr GENE PAGES

Alliance (1)

Gene:393897 (1)

VEGA:OTTDARG00000019638 (1)

Ensembl(GRCz11):ENSDARG00000006257 (2)

ORTHOLOGY for vldlr (Chr: 10)

CITATIONS (27)

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