Gene
vldlr
- ID
- ZDB-GENE-040426-803
- Name
- very low density lipoprotein receptor
- Symbol
- vldlr Nomenclature History
- Previous Names
-
- lr8 (1)
- zgc:55792
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have calcium ion binding activity and very-low-density lipoprotein particle receptor activity. Predicted to be involved in cholesterol metabolic process; endocytosis; and lipid transport. Predicted to localize to clathrin-coated pit; integral component of membrane; and very-low-density lipoprotein particle. Is expressed in several structures, including axis; brain; pronephric duct; retinal ganglion cell layer; and spinal cord interneuron. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, mental retardation and dysequlibrium syndrome; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55792 (8 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| cerebellar ataxia, mental retardation and dysequlibrium syndrome | Alliance | Cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1 | 224050 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Conserved_site | IPR023415 | Low-density lipoprotein (LDL) receptor class A, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Family | IPR032931 | Very low-density lipoprotein receptor |
| Homologous_superfamily | IPR011042 | Six-bladed beta-propeller, TolB-like |
| Homologous_superfamily | IPR036055 | LDL receptor-like superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
| Repeat | IPR000033 | LDLR class B repeat |
| Repeat | IPR002172 | Low-density lipoprotein (LDL) receptor class A repeat |
Domain Details Per Protein
| Protein | Length | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | LDLR class B repeat | LDL receptor-like superfamily | Low-density lipoprotein (LDL) receptor class A, conserved site | Low-density lipoprotein (LDL) receptor class A repeat | Six-bladed beta-propeller, TolB-like | Very low-density lipoprotein receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QKQ1
|
856 | ||||||||||
|
UniProtKB:A0A2R8QJ78
|
844 | ||||||||||
|
UniProtKB:E7FF13
|
866 | ||||||||||
|
UniProtKB:E9QBA5
|
842 | ||||||||||
|
UniProtKB:A0A0R4IGN2
|
863 |
Interactions and Pathways
No data available
Plasmids
No data available