ZFIN Gene: vldlr

ZFIN ID: ZDB-GENE-040426-803

ZFIN ID: ZDB-GENE-040426-803

Gene Name:

very low density lipoprotein receptor

Gene Symbol:

vldlr Nomenclature History

Previous Names:

lr8 (1), zgc:55792

Gene Type:

protein_coding_gene

Location:

Chr: 10 Mapping Details/Browsers

Description:

Predicted to have calcium ion binding activity and very-low-density lipoprotein particle receptor activity. Predicted to localize to integral component of membrane. Is expressed in several structures, including axis; brain; pronephric duct; retinal ganglion cell layer; and spinal cord interneuron. Human ortholog(s) of this gene implicated in Alzheimer's disease; cerebellar ataxia, mental retardation and dysequlibrium syndrome; and dementia. Orthologous to human VLDLR (very low density lipoprotein receptor).

Genome Resources:

Alliance (1), Gene:393897 (1), Ensembl(GRCz11):ENSDARG00000006257 (2)

GENE EXPRESSION
All Expression Data:	13 figures from 3 publications
Directly Submitted Expression Data:	6 figures (8 images) from Thisse et al., 2004 [MGC:55792]
Wild-type Stages, Structures:	Gastrula:Bud (10.0h-10.33h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
	axis brain central nervous system cerebellum dorsal telencephalon forebrain hindbrain hypothalamus immature eye midbrain ventral region optic tectum periventricular grey zone neuron pronephric duct retinal ganglion cell retinal ganglion cell layer rhombomere 2 rhombomere 3 rhombomere 4 rhombomere 5 rhombomere 6 spinal cord interneuron tegmentum telencephalon
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
ic3030	Insertion	Unknown	Unknown	CRISPR
sa14068	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa17714	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa38785	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
tud25Gt	Transgenic Insertion	Intron 2	Unknown	DNA	European Zebrafish Resource Center (EZRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-vldlr	ic3030	1

PHENOTYPE

Data:	3 figures from 2 publications
Observed in:	cerebellar Purkinje cell layer morphogenesis granular layer corpus cerebelli optic tectum neuron Purkinje cell Purkinje cell layer corpus cerebelli retinal ganglion cell neuron projection

DISEASE ASSOCIATED WITH vldlr HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
cerebellar ataxia, mental retardation and dysequlibrium syndrome	Alliance	Cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1	224050

DISEASE ASSOCIATED WITH vldlr VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Cellular Component	integral component of membrane (more)
Molecular Function	calcium ion binding (more)

GO Terms (all 4)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	vldlr-203 (1)	3496	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	vldlr-002 (1)	921	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	vldlr-003 (1)	752	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM vldlr No data available

MARKER RELATIONSHIPS

vldlr Contained in:	[BAC] CH211-241O7 (1)
vldlr Encodes:	[cDNA] MGC:55792 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_200923 (1)	3751 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR628386 (1)	148044 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7FF13 (1)	866 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 21)

ORTHOLOGY for vldlr ( Chr: 10 )

CITATIONS (30)

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