Gene
rp2
- ID
- ZDB-GENE-040426-2795
- Name
- RP2 activator of ARL3 GTPase
- Symbol
- rp2 Nomenclature History
- Previous Names
-
- nme10 (1)
- wu:fj10e02
- wu:fm72d05
- zgc:55632
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have GTPase activator activity. Involved in animal organ development; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Predicted to localize to cilium and periciliary membrane compartment. Is expressed in several structures, including fertilized egg; liver and biliary system; pleuroperitoneal region; sensory system; and trunk. Used to study retinitis pigmentosa 2. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Orthologous to human RP2 (RP2 activator of ARL3 GTPase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55632 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
Retinitis pigmentosa 2 | 312600 |
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
retinitis pigmentosa 2 | rp2hzu2/hzu2 | standard conditions | Liu et al., 2017 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR006599 | CARP motif |
Domain | IPR012945 | Tubulin binding cofactor C-like domain |
Domain | IPR017901 | C-CAP/cofactor C-like domain |
Family | IPR039093 | Protein XRP2 |
Homologous_superfamily | IPR016098 | Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal |
Homologous_superfamily | IPR036223 | Adenylate cyclase-associated CAP, C-terminal superfamily |
Homologous_superfamily | IPR036850 | Nucleoside diphosphate kinase-like domain superfamily |
Domain Details Per Protein
Protein | Length | Adenylate cyclase-associated CAP, C-terminal superfamily | CARP motif | C-CAP/cofactor C-like domain | Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal | Nucleoside diphosphate kinase-like domain superfamily | Protein XRP2 | Tubulin binding cofactor C-like domain |
---|---|---|---|---|---|---|---|---|
UniProtKB:F1QC45
|
376 |
Interactions and Pathways
No data available
Plasmids
No data available