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ZIRC
ZFIN ID: ZDB-GENE-040426-2795
Gene Name: RP2 activator of ARL3 GTPase
Gene Symbol: rp2    Nomenclature History

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Previous Names: nme10 (1), wu:fj10e02, wu:fm72d05, zgc:55632

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have GTP binding activity and GTPase activator activity. Involved in animal organ development; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Predicted to localize to the cilium and plasma membrane. Used to study retinitis pigmentosa 2. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Is expressed in several structures, including fertilized egg; liver and biliary system; pleuroperitoneal region; sensory system; and trunk. Orthologous to human RP2 (RP2 activator of ARL3 GTPase).
Genome Resources: Alliance (1),  Gene:406755 (1),  Ensembl(GRCz11):ENSDARG00000044339 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hzu1 Small Deletion Exon 2 Unknown TALEN
  • China Zebrafish Resource Center (CZRC) (order this)
  • hzu2 Small Deletion Unknown Inframe Deletion TALEN
    sa17284 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rp2 N/A 2
    MO2-rp2 N/A 1
    MO3-rp2 N/A 1
    MO4-rp2 N/A 1
    MO5-rp2 N/A 2
    TALEN1-rp2 2
    DISEASE ASSOCIATED WITH rp2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    retinitis pigmentosa 2 Alliance Retinitis pigmentosa 2 312600
    DISEASE ASSOCIATED WITH rp2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    retinitis pigmentosa 2 rp2hzu2/hzu2 standard conditions Liu et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process pronephros development (more)
    Cellular Component cell projection (more)
    Molecular Function GTPase activator activity (more)
    GO Terms (all 19)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rp2-201 (1)    Ensembl 2148
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab3-rp2 polyclonal IgG Rabbit WB ABclonal
    3
    Ab1-rp2 Rabbit IHC 2
    Ab5-rp2 polyclonal Rabbit IHC, WB 1
    Ab2-rp2 polyclonal Rabbit IHC Sigma-Aldrich
    2
    Ab4-rp2 Rabbit IHC, WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rp2 No data available
    MARKER RELATIONSHIPS
    rp2 Contained in: [BAC] DKEY-62E6 (1) (order this)
    rp2 Encodes: [EST] fj10e02, fm72d05 (1)
    [cDNA] MGC:55632 (1) (order this), MGC:192020 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213446 (1) 2020 bp
    Genomic GenBank:BX322552 (1) 230846 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1QC45 (1) 376 aa
    Sequence Clusters UniGene:161717 (1)
    Sequence Information (all 25)
    ORTHOLOGY for rp2 ( Chr: 6 )
    CITATIONS (34)