Gene

rp2

ID
ZDB-GENE-040426-2795
Name
RP2 activator of ARL3 GTPase
Symbol
rp2 Nomenclature History
Previous Names
  • nme10 (1)
  • wu:fj10e02
  • wu:fm72d05
  • zgc:55632
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have GTPase activator activity. Involved in animal organ development; photoreceptor cell maintenance; and photoreceptor cell outer segment organization. Predicted to localize to cilium and periciliary membrane compartment. Is expressed in several structures, including fertilized egg; liver and biliary system; pleuroperitoneal region; sensory system; and trunk. Used to study retinitis pigmentosa 2. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 2. Orthologous to human RP2 (RP2 activator of ARL3 GTPase).
Genome Resources
Note
None
Expression
All Expression Data
18 figures from 9 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 6 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rp2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
retinitis pigmentosa 2 Alliance Retinitis pigmentosa 2 312600
Associated With rp2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006599 CARP motif
Domain IPR012945 Tubulin binding cofactor C-like domain
Domain IPR017901 C-CAP/cofactor C-like domain
Domain IPR034907 Nucleoside diphosphate kinase-like domain
Family IPR039093 Protein XRP2
Homologous_superfamily IPR016098 Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal
Homologous_superfamily IPR036223 Adenylate cyclase-associated CAP, C-terminal superfamily
Homologous_superfamily IPR036850 Nucleoside diphosphate kinase-like domain superfamily
Domain Details Per Protein
Protein Length Adenylate cyclase-associated CAP, C-terminal superfamily CARP motif C-CAP/cofactor C-like domain Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal Nucleoside diphosphate kinase-like domain Nucleoside diphosphate kinase-like domain superfamily Protein XRP2 Tubulin binding cofactor C-like domain
UniProtKB:F1QC45 376
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-rp2 polyclonal IgG Rabbit
  • WB
ABclonal
3
Ab1-rp2 Rabbit
  • IHC
2
Ab5-rp2 polyclonal Rabbit
  • IHC
  • WB
1
Ab2-rp2 polyclonal Rabbit
  • IHC
Sigma-Aldrich
2
Ab4-rp2 Rabbit
  • IHC
  • WB
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations