ZFIN ID: ZDB-GENE-040426-2770
Gene Name: cofilin 1 (non-muscle), like
Gene Symbol: cfl1l    Nomenclature History

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Previous Names: cfl1, cb86 (1), sb:cb86, wu:fb18a04, wu:fk77b03, zgc:56501

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Predicted to be involved in actin filament fragmentation and cell motility. Predicted to localize to cortical actin cytoskeleton. Is expressed in EVL; epidermis; periderm; pharyngeal arch 3-7 skeleton; and pharynx. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2) and DSTN (destrin, actin depolymerizing factor).
Genome Resources: Alliance (1),  Gene:406738 (1),  Ensembl(GRCz11):ENSDARG00000012972 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2001 [cb86]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa5863 Point Mutation Unknown Splice Site ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cfl1l HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH cfl1l VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process actin filament depolymerization (more)
Cellular Component actin cytoskeleton (more)
Molecular Function actin binding (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cfl1l-201 (1)    Ensembl 1098
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
SignaFish
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-cfl1l polyclonal Rabbit 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cfl1l No data available
MARKER RELATIONSHIPS
cfl1l Contained in: [BAC] DKEY-76K16 (1) (order this)
cfl1l Encodes: [EST] cb86 (1) (order this), fb18a04 (1), fk77b03
[cDNA] MGC:56501 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_213639 (1) 967 nt
Genomic GenBank:BX005372 (1) 199736 nt
Select Tool
Polypeptide UniProtKB:Q7ZWD8 (1) 163 aa
Sequence Information (all 18)
ORTHOLOGY for cfl1l ( Chr: 13 )
CITATIONS (29)