Gene

cfl1l

ID
ZDB-GENE-040426-2770
Name
cofilin 1 (non-muscle), like
Symbol
cfl1l Nomenclature History
Previous Names
  • cfl1
  • cb86 (1)
  • sb:cb86
  • wu:fb18a04
  • wu:fk77b03
  • zgc:56501
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have actin filament binding activity. Predicted to be involved in actin filament fragmentation; actin filament severing; and cell motility. Predicted to localize to actin cytoskeleton and cytoplasm. Is expressed in EVL; epidermis; periderm; pharyngeal arch 3-7 skeleton; and pharynx. Human ortholog(s) of this gene implicated in nemaline myopathy 7. Orthologous to human CFL2 (cofilin 2) and DSTN (destrin, actin depolymerizing factor).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cfl1l Human Ortholog
No data available
Associated With cfl1l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002108 Actin-depolymerising factor homology domain
Family IPR017904 ADF/Cofilin
Homologous_superfamily IPR029006 ADF-H/Gelsolin-like domain superfamily
Domain Details Per Protein
Protein Length Actin-depolymerising factor homology domain ADF/Cofilin ADF-H/Gelsolin-like domain superfamily
UniProtKB:Q7ZWD8 163
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-cfl1l polyclonal Rabbit
Zebrafish International Resource Center (ZIRC)  (order this)
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations