Gene

cdk2

ID
ZDB-GENE-040426-2741
Name
cyclin-dependent kinase 2
Symbol
cdk2 Nomenclature History
Previous Names
  • wu:fa10c02
  • zgc:56598 (1)
  • zgc:77684 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; protein phosphorylation; and regulation of G2/M transition of mitotic cell cycle. Predicted to localize to cyclin-dependent protein kinase holoenzyme complex; cytoplasm; and nucleus. Is expressed in nervous system and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2).
Genome Resources
Note
None
Expression
All Expression Data
21 figures from 15 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cdk2 Human Ortholog
No data available
Associated With cdk2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:Q7ZWB1 298
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations