ZFIN ID: ZDB-GENE-040426-2741
Gene Name: cyclin-dependent kinase 2
Gene Symbol: cdk2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: wu:fa10c02, zgc:56598 (1), zgc:77684 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; protein phosphorylation; and regulation of G2/M transition of mitotic cell cycle. Predicted to localize to cyclin-dependent protein kinase holoenzyme complex; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Is expressed in nervous system and pharyngeal arch 3-7 skeleton. Orthologous to human CDK2 (cyclin dependent kinase 2).
Genome Resources: Alliance (1),  Gene:406715 (1),  Ensembl(GRCz11):ENSDARG00000026577 (2)
GENE EXPRESSION
All Expression Data: 20 figures from 14 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [MGC:56598]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa14988 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41762 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cdk2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cdk2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component cyclin-dependent protein kinase holoenzyme complex (more)
    Molecular Function ATP binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdk2-201 (1)    Ensembl 1734
    ncRNA cdk2-002 (1)    Ensembl 751
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM cdk2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(lyz:mcherry-2a-cdk2) lyz 2Acdk2mCherry Danio rerio 1 1
    tg(lyz:mcherry-2a-cdk2_d145n) lyz 2Acdk2mCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    cdk2 Contained in: [Fosmid] CH1073-182B19 (1)
    cdk2 Encodes: [EST] fa10c02 (1)
    [cDNA] MGC:56598 (1), MGC:77684
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213406 (1) 1619 nt
    Genomic GenBank:CU633767 (1) 38548 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZWB1 (1) 298 aa
    Sequence Information (all 16)
    ORTHOLOGY for cdk2 ( Chr: 11 )
    CITATIONS (65)