ZFIN ID: ZDB-GENE-040426-2719
Gene Name: pyruvate dehydrogenase E1 subunit alpha 1a
Gene Symbol: pdha1a    Nomenclature History

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Previous Names: pdha1, im:6895726, wu:fd18b01, wu:fo96f03, zgc:73271, zgc:86692

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to localize to mitochondrial pyruvate dehydrogenase complex. Is expressed in several structures, including adaxial cell; alar plate midbrain region; heart tube; musculature system; and pronephric duct. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to several human genes including PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1).
Genome Resources: Alliance (1),  Gene:406702 (1),  Ensembl(GRCz11):ENSDARG00000012387 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 4 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [IMAGE:6895726]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029069Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20403 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pdha1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pdha1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pyruvate decarboxylase deficiency Alliance Pyruvate dehydrogenase E1-alpha deficiency 312170
    DISEASE ASSOCIATED WITH pdha1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process acetyl-CoA biosynthetic process from pyruvate (more)
    Cellular Component intracellular membrane-bounded organelle (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pdha1a-201 (1)    Ensembl 2349
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdha1a No data available
    MARKER RELATIONSHIPS
    pdha1a Contained in: [BAC] CH211-114C12 (1)
    pdha1a Encodes: [EST] fd18b01 (1), fo96f03 (1), IMAGE:6895726 (1), IMAGE:7149029 (1)
    [cDNA] MGC:73271 (1), MGC:86692 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213393 (1) 2377 nt
    Genomic GenBank:AL928875 (1) 158038 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QAA8 (1) 410 aa
    Sequence Information (all 22)
    ORTHOLOGY for pdha1a ( Chr: 5 )
    CITATIONS (32)