ZFIN ID: ZDB-GENE-040426-2719
Gene Name: pyruvate dehydrogenase (lipoamide) alpha 1a
Gene Symbol: pdha1a

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: pdha1, im:6895726, wu:fd18b01, wu:fo96f03, zgc:73271, zgc:86692

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [IMAGE:6895726]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
  adaxial cell, alar plate midbrain region, eye, heart tube (all 10) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029069Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20403 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pdha1a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    pyruvate decarboxylase deficiency Pyruvate dehydrogenase E1-alpha deficiency 312170
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process acetyl-CoA biosynthetic process from pyruvate (more)
    Cellular Component intracellular membrane-bounded organelle (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001017 (1)
  • InterPro:IPR017597 (1)
  • InterPro:IPR029061 (1)
  • Pfam:PF00676 (1)
  • EC:1.2.4.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pdha1a-001 (1) 2349
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pdha1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pdha1aContained in: [BAC] CH211-114C12 (1) (order this)
    pdha1aEncodes: [EST] fd18b01 (1), fo96f03 (1), IMAGE:6895726 (1) (order this), IMAGE:7149029 (1) (order this)
    [cDNA] MGC:73271 (1) (order this), MGC:86692 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213393 (1) 2377bp
    Genomic GenBank:AL928875 (1) 158038bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IT09 (1) 400aa
    Sequence Clusters UniGene:75566 (1)
    Sequence Information (all 21)
    OTHER pdha1a GENE PAGES
  • Gene:406702 (1)
  • VEGA:OTTDARG00000016233 (1)
  • Ensembl(GRCz10):ENSDARG00000012387 (1)
  • ORTHOLOGY for pdha1a (Chr: 5)
    Species Symbol Chromosome Accession # Evidence
    Human PDHA1 X
  • Gene:5160
  • OMIM:300502
  • HGNC:8806
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (24)