header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-2719
Gene Name: pyruvate dehydrogenase E1 subunit alpha 1a
Gene Symbol: pdha1a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: pdha1, im:6895726, wu:fd18b01, wu:fo96f03, zgc:73271, zgc:86692

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate and oxidation-reduction process. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Is expressed in several structures, including adaxial cell; alar plate midbrain region; heart tube; musculature system; and pronephric duct. Orthologous to several human genes including PDHA1 (pyruvate dehydrogenase E1 alpha 1 subunit).
Genome Resources: Alliance (1),  Gene:406702 (1),  Ensembl(GRCz11):ENSDARG00000012387 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 4 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [IMAGE:6895726]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029069Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20403 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pdha1a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pdha1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pyruvate decarboxylase deficiency Alliance Pyruvate dehydrogenase E1-alpha deficiency 312170
    DISEASE ASSOCIATED WITH pdha1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process acetyl-CoA biosynthetic process from pyruvate (more)
    Cellular Component intracellular membrane-bounded organelle (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001017 (1)
  • InterPro:IPR017597 (1)
  • InterPro:IPR029061 (1)
  • Pfam:PF00676 (1)
  • EC:1.2.4.1 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pdha1a-201 (1)    Ensembl 2349
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdha1a No data available
    MARKER RELATIONSHIPS
    pdha1a Contained in: [BAC] CH211-114C12 (1) (order this)
    pdha1a Encodes: [EST] fd18b01 (1), fo96f03 (1), IMAGE:6895726 (1) (order this), IMAGE:7149029 (1) (order this)
    [cDNA] MGC:73271 (1) (order this), MGC:86692 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213393 (1) 2377 bp
    Genomic GenBank:AL928875 (1) 158038 bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QAA8 (1) 410 aa
    Sequence Clusters UniGene:75566 (1)
    Sequence Information (all 23)
    ORTHOLOGY for pdha1a ( Chr: 5 )
    CITATIONS (31)