Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-2719
Gene Name: pyruvate dehydrogenase (lipoamide) alpha 1a
Gene Symbol: pdha1a
Previous Names: pdha1, im:6895726, wu:fd18b01, wu:fo96f03, zgc:73271, zgc:86692
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (11 images) from Thisse et al., 2004 [IMAGE:6895726]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Hatching:Long-pec (48.0h-60.0h)
  adaxial cell, alar plate midbrain region, eye, heart tube (all 10) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la029069Tg, sa20403
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
Leigh syndrome, X-linked 308930
Pyruvate dehydrogenase E1-alpha deficiency 312170
GENE ONTOLOGY
Ontology GO Term
Biological Process glycolytic process (more)
Cellular Component intracellular membrane-bounded organelle (more)
Molecular Function oxidoreductase activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001017 (1)
  • InterPro:IPR017597 (1)
  • InterPro:IPR029061 (1)
  • Pfam:PF00676 (1)
  • EC:1.2.4.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pdha1a-001 (1) 2349
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdha1a No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    pdha1a Contained in: [BAC] CH211-114C12 (1) (order this)
    pdha1a Encodes: [EST] fd18b01 (1), fo96f03 (1), IMAGE:6895726 (1) (order this), IMAGE:7149029 (1) (order this)
    [cDNA] MGC:73271 (1) (order this), MGC:86692 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_213393 (1) 2377 bp
    Genomic GenBank:AL928875 (1) 158038 bp
    Select Tool
    Polypeptide UniProtKB:Q6P948 (1) 393 aa
    Sequence Clusters UniGene:75566 (1)
    Sequence Information (all 20)
    OTHER pdha1a GENE PAGES
  • Gene:406702 (1)
  • VEGA:OTTDARG00000016233 (1)
  • Ensembl(Zv9):ENSDARG00000012387 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish pdha1a 5  
    Human PDHA1 X (Xp22.1)
  • OMIM:300502
  • Gene:5160
  • Orthology Details
    CITATIONS (23)