| ZFIN ID: ZDB-GENE-040426-2709 |
| Gene Name: | VRK serine/threonine kinase 1 | |||||||||||||
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| Gene Symbol: | vrk1 Nomenclature History |
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Attributions
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| Previous Names: | wu:fe16f06, zgc:56266 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Ambiguous Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have protein serine/threonine kinase activity. Predicted to be involved in Golgi disassembly; Wnt signaling pathway; and peptidyl-serine phosphorylation. Predicted to localize to Golgi stack and nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:406694 (1), Ensembl(GRCz11):ENSDARG00000018006 (1) | |||||||||||||
| Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2004 [MGC:56266] |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h) |
| High Throughput Expression: | GEO (1) , Expression Atlas (1) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| sa23040 | Point Mutation | Unknown | Premature Stop | ENU |
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| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| pontocerebellar hypoplasia type 1A | Alliance | Pontocerebellar hypoplasia type 1A | 607596 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | Golgi disassembly (more) |
| Cellular Component | Golgi stack (more) |
| Molecular Function | ATP binding (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
vrk1-201
(1)
|
1542 |
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|
|
| ncRNA |
vrk1-002
(1)
|
448 |
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|
| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM vrk1
No data available
MARKER RELATIONSHIPS
| vrk1 Contained in: |
[BAC]
CH211-135E15 (1)
[Fosmid] CH1073-432E22 (1) |
| vrk1 Encodes: |
[EST]
fe16f06 (1)
[cDNA] MGC:56266 (1), MGC:174836 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_213385 (1) | 1562 nt |
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| Genomic | GenBank:CU467823 (1) | 135288 nt | |
| Polypeptide | UniProtKB:A7MCR4 (1) | 425 aa |
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ORTHOLOGY for vrk1 (
Ambiguous
)
CITATIONS (23)