ZFIN ID: ZDB-GENE-040426-2709
Gene Name: VRK serine/threonine kinase 1
Gene Symbol: vrk1    Nomenclature History

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Previous Names: wu:fe16f06, zgc:56266

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Ambiguous Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Predicted to be involved in Golgi disassembly; Wnt signaling pathway; and peptidyl-serine phosphorylation. Predicted to localize to Golgi stack and nucleus. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1A. Orthologous to human VRK1 (VRK serine/threonine kinase 1).
Genome Resources: Alliance (1),  Gene:406694 (1),  Ensembl(GRCz11):ENSDARG00000018006 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56266]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23040 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH vrk1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    pontocerebellar hypoplasia type 1A Alliance Pontocerebellar hypoplasia type 1A 607596
    DISEASE ASSOCIATED WITH vrk1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Golgi disassembly (more)
    Cellular Component Golgi stack (more)
    Molecular Function ATP binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vrk1-201 (1)    Ensembl 1542
    ncRNA vrk1-002 (1)    Ensembl 448
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vrk1 No data available
    MARKER RELATIONSHIPS
    vrk1 Contained in: [BAC] CH211-135E15 (1)
    [Fosmid] CH1073-432E22 (1)
    vrk1 Encodes: [EST] fe16f06 (1)
    [cDNA] MGC:56266 (1), MGC:174836 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213385 (1) 1562 nt
    Genomic GenBank:CU467823 (1) 135288 nt
    Select Tool
    Polypeptide UniProtKB:A7MCR4 (1) 425 aa
    Sequence Information (all 18)
    ORTHOLOGY for vrk1 ( Ambiguous )
    CITATIONS (23)