ZFIN ID: ZDB-GENE-040426-2477
Gene Name: leukotriene A4 hydrolase
Gene Symbol: lta4h    Nomenclature History

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Previous Name: zgc:85809

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have epoxide hydrolase activity and leukotriene-A4 hydrolase activity. Involved in several processes, including epiboly involved in gastrulation with mouth forming second; neutrophil chemotaxis; and response to bacterium. Predicted to localize to nucleus. Is expressed in intestinal bulb; macrophage; and neutrophil. Orthologous to human LTA4H (leukotriene A4 hydrolase).
Genome Resources: Alliance (1),  Gene:406575 (1),  Ensembl(GRCz11):ENSDARG00000006029 (1)
GENE EXPRESSION
All Expression Data: 10 figures from 4 publications
Directly Submitted Expression Data: 7 figures (7 images) from Thisse et al., 2004 [IMAGE:7148006]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh112 Point Mutation Unknown Unknown ENU
zm5961Tg Transgenic Insertion Unknown Unknown DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-lta4h N/A 8
MO2-lta4h N/A 1
DISEASE ASSOCIATED WITH lta4h HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH lta4h VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process epiboly involved in gastrulation with mouth forming second (more)
Cellular Component cytoplasm (more)
Molecular Function hydrolase activity (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA lta4h-201 (1)    Ensembl 2151
ncRNA lta4h-002 (1)    Ensembl 607
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM lta4h
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(lyz:lta4h-2A-mCherry) lyz 2Alta4hmCherry Danio rerio 1 2
MARKER RELATIONSHIPS
lta4h Contained in: [BAC] CH211-136G2 (1), CH211-157E21 (1), CH211-172B12 (1)
lta4h Encodes: [EST] IMAGE:7148006 (1)
[cDNA] MGC:85809 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_213286 (1) 2209 nt
Genomic GenBank:BX649411 (1) 180557 nt
Select Tool
Polypeptide UniProtKB:A5PMQ1 (1) 611 aa
Sequence Information (all 16)
ORTHOLOGY for lta4h ( Chr: 4 )
CITATIONS (37)