Gene

lta4h

ID
ZDB-GENE-040426-2477
Name
leukotriene A4 hydrolase
Symbol
lta4h Nomenclature History
Previous Names
  • zgc:85809
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have epoxide hydrolase activity and leukotriene-A4 hydrolase activity. Involved in several processes, including epiboly involved in gastrulation with mouth forming second; neutrophil chemotaxis; and response to bacterium. Predicted to localize to nucleus. Is expressed in intestinal bulb; macrophage; and neutrophil. Orthologous to human LTA4H (leukotriene A4 hydrolase).
Genome Resources
Note
None
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lta4h Human Ortholog
No data available
Associated With lta4h Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR014782 Peptidase M1, membrane alanine aminopeptidase
Domain IPR015211 Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal
Family IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
Family IPR012777 Leukotriene A4 hydrolase/leucine aminopeptidase
Family IPR034015 Aminopeptidase, leukotriene A4 hydrolase-like
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR027268 Peptidase M4/M1, CTD superfamily
Homologous_superfamily IPR038502 Peptidase M1 LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily
Homologous_superfamily IPR042097 Aminopeptidase N-like , N-terminal
Domain Details Per Protein
Protein Length Aminopeptidase, leukotriene A4 hydrolase-like Aminopeptidase N-like , N-terminal Armadillo-type fold Leukotriene A4 hydrolase/leucine aminopeptidase Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal Peptidase M1 LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily Peptidase M1, membrane alanine aminopeptidase Peptidase M4/M1, CTD superfamily
UniProtKB:Q5RIF1 611
UniProtKB:Q5RIF2 205
UniProtKB:A5PMQ1 611
UniProtKB:Q6NUX4 611
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations