ZFIN Gene: rps19

ZFIN ID: ZDB-GENE-040426-1716

ZFIN ID: ZDB-GENE-040426-1716

Gene Name:

ribosomal protein S19

Gene Symbol:

rps19 Nomenclature History

Previous Name:

zgc:73211 (1)

Gene Type:

protein_coding_gene

Location:

Chr: 16 Mapping Details/Browsers

Description:

Contributes as a structural constituent of ribosome. Involved in several processes, including brain segmentation; erythrocyte development; and hemoglobin biosynthetic process. Localizes to ribosome. Used to study Diamond-Blackfan anemia and aplastic anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia. Orthologous to human RPS19 (ribosomal protein S19).

Genome Resources:

Alliance (1), Gene:393723 (1), Ensembl(GRCz11):ENSDARG00000030602 (2)

GENE EXPRESSION
All Expression Data:	Fig. 1 from Danilova et al., 2008
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Long-pec (48.0h-60.0h)
	whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
zf556	Indel	Intron 2 - Exon 3 Splice Junction	Unknown	TALEN
zf557	Small Deletion	Intron 2 - Exon 3 Splice Junction	Unknown	TALEN

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-rps19	N/A	10
MO2-rps19	N/A	4
TALEN1-rps19	zf556 zf557	1

PHENOTYPE

Data:

29 figures from 13 publications

Observed in:

DISEASE ASSOCIATED WITH rps19 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Diamond-Blackfan anemia 1	Alliance	Diamond-Blackfan anemia 1	105650

DISEASE ASSOCIATED WITH rps19 VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
aplastic anemia	AB + MO1-rps19 + MO4-tp53	standard conditions	Jia et al., 2013
Diamond-Blackfan anemia	AB + MO1-rps19	standard conditions	Jia et al., 2013
	AB + MO2-rps19	standard conditions	Danilova et al., 2018
	rps19^zf556/zf556	standard conditions	(2)
	WT + MO2-rps19	control	(2)

GENE ONTOLOGY

Ontology	GO Term
Biological Process	intrinsic apoptotic signaling pathway by p53 class mediator (more)
Cellular Component	ribosome (more)
Molecular Function	CONTRIBUTES_TO structural constituent of ribosome (more)

GO Terms (all 14)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	rps19-201 (1)	631	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	rps19-202 (1)	861	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM rps19 No data available

MARKER RELATIONSHIPS

rps19 Contained in:	[BAC] CH211-213B7 (1)
rps19 Encodes:	[cDNA] MGC:73211 (1), MGC:173970 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_200750 (1)	492 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR391920 (1)	199710 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A0R4IJ49 (1)	152 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 14)

ORTHOLOGY for rps19 ( Chr: 16 )

CITATIONS (35)

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