ZFIN ID: ZDB-GENE-040426-1378
Gene Name: speckle type BTB/POZ protein
Gene Symbol: spop    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:64140

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to localize to the Cul3-RING ubiquitin ligase complex; cytoplasm; and nucleus. Orthologous to human SPOP (speckle type BTB/POZ protein).
Genome Resources: Alliance (1),  Gene:100005514 (1),  Ensembl(GRCz11):ENSDARG00000100519 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:64140]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9950 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18300 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40045 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-spop
    2
    MO1-spop N/A 1
    MO2-spop N/A 1
    DISEASE ASSOCIATED WITH spop HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH spop VIA EXPERIMENTAL MODELS No data available
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000210 BTB/POZ domain
    Domain IPR002083 MATH/TRAF domain
    Homologous_superfamily IPR008974 TRAF-like
    Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA spop-202 (1)    Ensembl 2448
    ncRNA spop-002 (1) 535
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM spop No data available
    MARKER RELATIONSHIPS
    spop Contained in: [BAC] CH73-348M5 (1), CH211-152J7 (1), CH211-213I9 (1), DKEY-66B12 (1) (order this)
    spop Encodes: [cDNA] MGC:64140 (1), MGC:174052 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201130 (1) 2254 bp
    Genomic GenBank:BX248239 (1) 200856 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A7YYH8 (1) 374 aa
    Sequence Information (all 20)
    ORTHOLOGY for spop ( Chr: 3 )
    CITATIONS (25)