Gene

hif1al

ID
ZDB-GENE-040426-1315
Name
hypoxia inducible factor 1 subunit alpha, like
Symbol
hif1al Nomenclature History
Previous Names
  • hif-3 (1)
  • Hif3a (1)
  • zgc:63965
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Exhibits beta-catenin binding activity and transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including neuron apoptotic process; response to activity; and response to hypoxia. Localizes to beta-catenin-TCF complex. Is expressed in several structures, including digestive system; head; heart; inner ear; and pleuroperitoneal region. Orthologous to human HIF3A (hypoxia inducible factor 3 subunit alpha).
Genome Resources
Note
None
Expression
All Expression Data
11 figures from 9 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Zhang et al., 2016
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hif1al Human Ortholog
No data available
Associated With hif1al Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000014 PAS domain
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR013655 PAS fold-3
Domain IPR013767 PAS fold
Family IPR001067 Nuclear translocator
Family IPR021537 Hypoxia-inducible factor, alpha subunit
Homologous_superfamily IPR035965 PAS domain superfamily
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Repeat IPR001610 PAC motif
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Hypoxia-inducible factor, alpha subunit Myc-type, basic helix-loop-helix (bHLH) domain Nuclear translocator PAC motif PAS domain PAS domain superfamily PAS fold PAS fold-3
UniProtKB:A9JRN3 170
UniProtKB:Q7T2E4 571
UniProtKB:F1A7S2 170
UniProtKB:F1A7S1 626
UniProtKB:Q6EGR9 626
UniProtKB:A0A0R4IB28 619
UniProtKB:A0A0R4IRI4 221
UniProtKB:A0A0R4IBR4 626
UniProtKB:F1A7S3 199
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-hif1al polyclonal Rabbit
  • WB
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations