ZFIN ID: ZDB-GENE-040116-3
Gene Name: platelet-activating factor acetylhydrolase 1b, regulatory subunit 1b
Gene Symbol: pafah1b1b    Nomenclature History

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Previous Name: lis1a (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have dynein complex binding activity and microtubule plus-end binding activity. Involved in several processes, including apical protein localization; brain morphogenesis; and photoreceptor cell maintenance. Localizes to cytoplasm. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lissencephaly. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1).
Genome Resources: Alliance (1),  Gene:394247 (1),  Ensembl(GRCz11):ENSDARG00000026595 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa25167 Point Mutation Unknown Splice Site ENU
sa43704 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pafah1b1b N/A 2
    MO2-pafah1b1b N/A 1
    DISEASE ASSOCIATED WITH pafah1b1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    lissencephaly Alliance Lissencephaly 1 607432
    Subcortical laminar heterotopia 607432
    DISEASE ASSOCIATED WITH pafah1b1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain morphogenesis (more)
    Cellular Component cytoplasm (more)
    Molecular Function dynein complex binding (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pafah1b1b-201 (1)    Ensembl 3183
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-pafah1b1 polyclonal Rabbit WB 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pafah1b1b No data available
    MARKER RELATIONSHIPS
    pafah1b1b Contained in: [BAC] CH211-232P9 (1), CH211-274P24 (1)
    pafah1b1b Encodes: [cDNA] MGC:55898 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201346 (1) 1728 nt
    Genomic GenBank:AL929224 (1) 176879 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4I9B2 (1) 410 aa
    Sequence Information (all 15)
    ORTHOLOGY for pafah1b1b ( Chr: 21 )
    CITATIONS (27)