ZFIN ID: ZDB-GENE-040116-2
Gene Name: platelet-activating factor acetylhydrolase 1b, regulatory subunit 1a
Gene Symbol: pafah1b1a    Nomenclature History

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Previous Name: lis1b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have dynein complex binding activity and microtubule plus-end binding activity. Involved in brain morphogenesis. Localizes to cytoplasm. Is expressed in several structures, including gill; heart; liver; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in lissencephaly. Orthologous to human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1).
Genome Resources: Alliance (1),  Gene:394246 (1),  Ensembl(GRCz11):ENSDARG00000032013 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pafah1b1a N/A 1
MO2-pafah1b1a N/A 1
DISEASE ASSOCIATED WITH pafah1b1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
lissencephaly Alliance Lissencephaly 1 607432
Subcortical laminar heterotopia 607432
DISEASE ASSOCIATED WITH pafah1b1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process brain morphogenesis (more)
Cellular Component cytoplasm (more)
Molecular Function dynein complex binding (more)
GO Terms (all 26)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pafah1b1a-201 (1)    Ensembl 2252
ncRNA pafah1b1a-002 (1)    Ensembl 746
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-pafah1b1 polyclonal Rabbit WB 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pafah1b1a No data available
MARKER RELATIONSHIPS
pafah1b1a Contained in: [BAC] DKEY-95O3 (1) (order this)
pafah1b1a Encodes: [EST] IMAGE:7136312 (1)
[cDNA] MGC:64021 (1), MGC:192031 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_201345 (1) 1786 nt
Genomic GenBank:BX324162 (1) 155540 nt
Select Tool
Polypeptide UniProtKB:B2GQS8 (1) 410 aa
Sequence Information (all 20)
ORTHOLOGY for pafah1b1a ( Chr: 15 )
CITATIONS (28)