Gene
mmp13a.1
- ID
- ZDB-GENE-031202-2
- Name
- matrix metallopeptidase 13a, tandem duplicate 1
- Symbol
- mmp13a.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to have metalloendopeptidase activity. Involved in macrophage chemotaxis. Predicted to localize to extracellular matrix. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); bone disease (multiple); and ovarian carcinoma. Is expressed in several structures, including cardiovascular system; extension; head; intermediate cell mass of mesoderm; and leukocyte. Orthologous to human MMP13 (matrix metallopeptidase 13).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 56 figures from 45 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb1034 (5 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondyloepimetaphyseal dysplasia, Missouri type | Alliance | Metaphyseal anadysplasia 1 | 602111 |
| spondyloepimetaphyseal dysplasia, Missouri type | Alliance | ?Spondyloepimetaphyseal dysplasia, Missouri type | 602111 |
| Metaphyseal dysplasia, Spahr type | 250400 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR021158 | Peptidase M10A, cysteine switch, zinc binding site |
| Conserved_site | IPR018486 | Hemopexin, conserved site |
| Domain | IPR000585 | Hemopexin-like domain |
| Domain | IPR001818 | Peptidase M10, metallopeptidase |
| Domain | IPR002477 | Peptidoglycan binding-like |
| Domain | IPR006026 | Peptidase, metallopeptidase |
| Domain | IPR033739 | Peptidase M10A, catalytic domain |
| Family | IPR021190 | Peptidase M10A |
| Homologous_superfamily | IPR024079 | Metallopeptidase, catalytic domain superfamily |
| Homologous_superfamily | IPR036365 | PGBD-like superfamily |
| Homologous_superfamily | IPR036375 | Hemopexin-like domain superfamily |
| Repeat | IPR018487 | Hemopexin-like repeats |
Domain Details Per Protein
| Protein | Length | Hemopexin, conserved site | Hemopexin-like domain | Hemopexin-like domain superfamily | Hemopexin-like repeats | Metallopeptidase, catalytic domain superfamily | Peptidase M10A | Peptidase M10A, catalytic domain | Peptidase M10A, cysteine switch, zinc binding site | Peptidase M10, metallopeptidase | Peptidase, metallopeptidase | Peptidoglycan binding-like | PGBD-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1P6J4
|
476 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-mmp13a | polyclonal | IgG | Rabbit |
|
AnaSpec
|
4 |
Plasmids
No data available