ZFIN ID: ZDB-GENE-031202-2
Gene Name: matrix metallopeptidase 13a
Gene Symbol: mmp13a    Nomenclature History

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Previous Names: mmp13, MMPLg, MMPLh (1), cb1034 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Involved in macrophage chemotaxis. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); female reproductive organ cancer (multiple); obstructive lung disease (multiple); scleroderma (multiple); and urinary system cancer (multiple). Is expressed in several structures, including cardiovascular system; extension; head; intermediate cell mass of mesoderm; and leukocyte. Orthologous to several human genes including MMP1 (matrix metallopeptidase 1); MMP10 (matrix metallopeptidase 10); and MMP13 (matrix metallopeptidase 13).
Genome Resources: Alliance (1),  Gene:387293 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34965 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41716 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mmp13a N/A 2
    MO2-mmp13a N/A 3
    DISEASE ASSOCIATED WITH mmp13a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spondyloepimetaphyseal dysplasia, Missouri type Alliance Metaphyseal anadysplasia 1 602111
    Spondyloepimetaphyseal dysplasia, Missouri type 602111
    Metaphyseal dysplasia, Spahr type 250400
    DISEASE ASSOCIATED WITH mmp13a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process macrophage chemotaxis (more)
    Cellular Component extracellular matrix (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR021158 Peptidase M10A, cysteine switch, zinc binding site
    Conserved_site IPR018486 Hemopexin, conserved site
    Domain IPR000585 Hemopexin-like domain
    Domain IPR001818 Peptidase M10, metallopeptidase
    Domain IPR002477 Peptidoglycan binding-like
    Domain IPR006026 Peptidase, metallopeptidase
    Domain IPR033739 Peptidase M10A, catalytic domain
    Family IPR021190 Peptidase M10A
    Family IPR028711 Collagenase 3
    Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
    Homologous_superfamily IPR036365 PGBD-like superfamily
    Homologous_superfamily IPR036366 PGBD superfamily
    Homologous_superfamily IPR036375 Hemopexin-like domain superfamily
    Repeat IPR018487 Hemopexin-like repeats
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mmp13a polyclonal IgG Rabbit AnaSpec
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mmp13a No data available
    MARKER RELATIONSHIPS
    mmp13a Encodes: [EST] cb1034 (1) (order this)
    [cDNA] MGC:56521 (1), MGC:77179 (1), MGC:173926 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001290479 (1)
    Genomic GenBank:FP236276 (1) 43995 nt
    Select Tool
    Polypeptide UniProtKB:B0JZI6 (1) 476 aa
    Sequence Information (all 29)
    ORTHOLOGY for mmp13a ( Chr: 10 )
    CITATIONS (104)