ZFIN ID: ZDB-GENE-031202-2
Gene Name: matrix metallopeptidase 13a
Gene Symbol: mmp13a    Nomenclature History

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Previous Names: mmp13, MMPLg, MMPLh (1), cb1034 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Involved in macrophage chemotaxis. Predicted to localize to extracellular matrix. Is expressed in several structures, including cardiovascular system; extension; head; intermediate cell mass of mesoderm; and leukocyte. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); bone disease (multiple); and ovarian carcinoma. Orthologous to human MMP13 (matrix metallopeptidase 13).
Genome Resources: Alliance (1),  Gene:387293 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa34965 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41716 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mmp13a N/A 2
    MO2-mmp13a N/A 3
    DISEASE ASSOCIATED WITH mmp13a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spondyloepimetaphyseal dysplasia, Missouri type Alliance Metaphyseal anadysplasia 1 602111
    Spondyloepimetaphyseal dysplasia, Missouri type 602111
    Metaphyseal dysplasia, Spahr type 250400
    DISEASE ASSOCIATED WITH mmp13a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process macrophage chemotaxis (more)
    Cellular Component extracellular matrix (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-mmp13a polyclonal IgG Rabbit AnaSpec
    4
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mmp13a No data available
    MARKER RELATIONSHIPS
    mmp13a Encodes: [EST] cb1034 (1) (order this)
    [cDNA] MGC:56521 (1), MGC:77179 (1), MGC:173926 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001290479 (1)
    Genomic GenBank:FP236276 (1) 43995 nt
    Select Tool
    Polypeptide UniProtKB:B0JZI6 (1) 476 aa
    Sequence Information (all 29)
    ORTHOLOGY for mmp13a ( Chr: 10 )
    CITATIONS (106)