ZFIN ID: ZDB-GENE-031112-7
Gene Name: APC regulator of WNT signaling pathway
Gene Symbol: apc    Nomenclature History

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Previous Names: cb965 (1), im:7150932, im:7152872

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have beta-catenin binding activity; microtubule binding activity; and protein kinase regulator activity. Involved in several processes, including animal organ development; chordate embryonic development; and embryonic pectoral fin morphogenesis. Predicted to localize to several cellular components, including beta-catenin destruction complex; centrosome; and lateral plasma membrane. Is expressed in hypochord; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway).
Genome Resources: Alliance (1),  Gene:386762 (1),  Ensembl(GRCz11):ENSDARG00000058868 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu745 Point Mutation Unknown Premature Stop ENU
ihb345 Small Deletion Exon 14 Unknown CRISPR
ihb346 Small Deletion Exon 14 Unknown CRISPR
ihb347 Small Deletion Exon 15 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa61 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6136 Point Mutation Unknown Premature Stop ENU
    sa9511 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12033 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21628 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27530 Point Mutation Unknown Premature Stop ENU
    sa34805 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sd58 Point Mutation Unknown Unknown ENU
    zf134 Point Mutation Unknown Premature Stop
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-apc 1
    CRISPR2-apc 1
    MO1-apc N/A 9
    MO2-apc N/A 1
    MO3-apc N/A 1
    PHENOTYPE
    Data: 60 figures from 23 publications
    Observed in:
    DISEASE ASSOCIATED WITH apc HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    familial adenomatous polyposis 1 Alliance Adenomatous polyposis coli 175100
    Brain tumor-polyposis syndrome 2 175100
    Gardner syndrome 175100
    hepatocellular carcinoma Alliance Hepatoblastoma, somatic 114550
    hereditary desmoid disease Alliance Desmoid disease, hereditary 135290
    stomach cancer Alliance Gastric cancer, somatic 613659
    Adenoma, periampullary, somatic
    DISEASE ASSOCIATED WITH apc VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process liver development (more)
    Cellular Component beta-catenin destruction complex (more)
    Molecular Function beta-catenin binding (more)
    GO Terms (all 53)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apc-201 (1)    Ensembl 9187
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apc No data available
    MARKER RELATIONSHIPS
    apc Contained in: [BAC] CH73-238M11 (1)
    [Fosmid] CH1073-190G7 (1)
    apc Encodes: [EST] cb965 (1) (order this), IMAGE:7150932 (1), IMAGE:7152872 (1)
    [STS] zfish44906-1822h03.q1k
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001143840 (1) 9214 nt
    Genomic GenBank:CU861476 (1) 86052 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IWH7 (1) 2754 aa
    Sequence Information (all 20)
    ORTHOLOGY for apc ( Chr: 10 )
    CITATIONS (87)