ZFIN ID: ZDB-GENE-031112-7
Gene Name: adenomatous polyposis coli
Gene Symbol: apc
Previous Names: cb965 (1), im:7150932, im:7152872
Location: Chr: 10   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 17 figures from 4 publications
Directly Submitted Expression Data: 5 figures (8 images) from Thisse et al., 2004 [IMAGE:7150932]
  6 figures (7 images) from Thisse et al., 2004 [IMAGE:7152872]
  5 figures (9 images) from Thisse et al., 2001 [cb965]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Hatching:Long-pec (48.0h-60.0h)
  basal plate midbrain region, central nervous system, cranial ganglion, diencephalon (all 17) expand
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 32 Genotypes
Knockdown reagents: MO1-apc (1), MO2-apc (1)

Allele Type Mutagen Suppliers
hu745 Point Mutation ENU
sa61 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9511 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12033 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • zf134 Point Mutation
    PHENOTYPE
    Data: 54 figures from 19 publications
    Observed in: anterior commissure, anterior/posterior axis specification, atrioventricular canal, atrioventricular canal endocardium (all 99) expand
    DISEASE ASSOCIATED WITH apc HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    familial adenomatous polyposis Adenomatous polyposis coli 175100
    Brain tumor-polyposis syndrome 2 175100
    colon carcinoma Colorectal cancer, somatic 114500
    familial adenomatous polyposis Gardner syndrome 175100
    stomach cancer Gastric cancer, somatic 613659
    hepatocellular carcinoma Hepatoblastoma, somatic 114550
    Desmoid disease, hereditary 135290
    Adenoma, periampullary, somatic
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process Wnt signaling pathway involved in somitogenesis (more)
    Cellular Component beta-catenin destruction complex (more)
    Molecular Function beta-catenin binding (more)
    GO Terms (all 59)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000225 (1)
  • InterPro:IPR009223 (1)
  • InterPro:IPR009224 (1)
  • InterPro:IPR009232 (1)
  • InterPro:IPR009234 (1)
  • InterPro:IPR009240 (1)
  • InterPro:IPR011989 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR026818 (1)
  • InterPro:IPR026831 (1)
  • InterPro:IPR026836 (1)
  • PROSITE:PS50176 (1)
  • Pfam:PF00514 (1)
  • Pfam:PF05923 (1)
  • Pfam:PF05924 (1)
  • Pfam:PF05937 (1)
  • Pfam:PF05956 (1)
  • Pfam:PF05972 (1)
  • Pfam:PF11414 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA apc-001 (1) 9187
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apc No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    apc Contained in: [BAC] CH73-238M11 (1) (order this)
    [Fosmid] CH1073-190G7 (1) (order this)
    apc Encodes: [EST] cb965 (1) (order this), IMAGE:7150932 (1) (order this), IMAGE:7152872 (1) (order this)
    [STS] zfish44906-1822h03.q1k
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001143840 (1) 9214 bp
    Genomic GenBank:CU861476 (1) 86052 bp
    Select Tool
    Polypeptide UniProtKB:F1QN37 (1) 2755 aa
    Sequence Clusters UniGene:160758 (1)
    Sequence Information (all 17)
    OTHER apc GENE PAGES
  • Gene:386762 (1)
  • VEGA:OTTDARG00000035536 (1)
  • Ensembl(Zv9):ENSDARG00000058868 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish apc 10  
    Human APC 5 (5q21-q22)
  • OMIM:611731
  • Gene:324
  • Mouse Apc 18 ( 18.53 cM)
  • MGI:88039
  • Gene:11789
  • Orthology Details
    CITATIONS (60)