Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-031112-7
Gene Name: adenomatous polyposis coli
Gene Symbol: apc
Previous Names: cb965 (1), im:7150932, im:7152872
Location: Chr: 10   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 17 figures from 3 publications
Directly Submitted Expression Data: 5 figures (8 images) from Thisse et al., 2004 [IMAGE:7150932]
  6 figures (7 images) from Thisse et al., 2004 [IMAGE:7152872]
  5 figures (9 images) from Thisse et al., 2001 [cb965]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Hatching:Long-pec (48.0h-60.0h)
  basal plate midbrain region, central nervous system, cranial ganglion, diencephalon (all 17) expand
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 32 genotypes
Alleles: hu745, sa12033, sa61, sa9511, zf134
Knockdown reagents: MO1-apc (1), MO2-apc (1)
PHENOTYPE
Data: 49 figures from 16 publications
Observed in: anterior commissure, anterior/posterior axis specification, atrioventricular canal, atrioventricular canal endocardium (all 84) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Adenoma, periampullary, somatic
Adenomatous polyposis coli 175100
Brain tumor-polyposis syndrome 2 175100
Colorectal cancer, somatic 114500
Desmoid disease, hereditary 135290
Gardner syndrome 175100
Gastric cancer, somatic 613659
Hepatoblastoma, somatic 114550
GENE ONTOLOGY
Ontology GO Term
Biological Process Wnt signaling pathway involved in somitogenesis (more)
Cellular Component beta-catenin destruction complex (more)
Molecular Function beta-catenin binding (more)
GO Terms (all 53)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000225 (1)
  • InterPro:IPR009223 (1)
  • InterPro:IPR009224 (1)
  • InterPro:IPR009232 (1)
  • InterPro:IPR009234 (1)
  • InterPro:IPR009240 (1)
  • InterPro:IPR011989 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR026818 (1)
  • InterPro:IPR026831 (1)
  • InterPro:IPR026836 (1)
  • PROSITE:PS50176 (1)
  • Pfam:PF00514 (1)
  • Pfam:PF05923 (1)
  • Pfam:PF05924 (1)
  • Pfam:PF05937 (1)
  • Pfam:PF05956 (1)
  • Pfam:PF05972 (1)
  • Pfam:PF11414 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA apc-001 (1) 9187
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apc No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    apc Contained in: [BAC] CH73-238M11 (1) (order this)
    [Fosmid] CH1073-190G7 (1) (order this)
    apc Encodes: [EST] cb965 (1) (order this), IMAGE:7150932 (1) (order this), IMAGE:7152872 (1) (order this)
    [STS] zfish44906-1822h03.q1k
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001143840 (1) 9214 bp
    Genomic GenBank:CU861476 (1) 86052 bp
    Select Tool
    Polypeptide UniProtKB:F1QN37 (1) 2755 aa
    Sequence Clusters UniGene:76198 (1)
    Sequence Information (all 17)
    OTHER apc GENE PAGES
  • Gene:386762 (1)
  • VEGA:OTTDARG00000035536 (1)
  • Ensembl(Zv9):ENSDARG00000058868 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish apc 10  
    Human APC 5 (5q21-q22)
  • OMIM:611731
  • Gene:324
  • Mouse Apc 18 ( 18.53 cM)
  • MGI:88039
  • Gene:11789
  • Orthology Details
    CITATIONS (56)