ZFIN ID: ZDB-GENE-031112-7
Gene Name: adenomatous polyposis coli
Gene Symbol: apc
Sequence Ontology ID : SO:0000704

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Previous Names: cb965 (1), im:7150932, im:7152872

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(Including Attributions)
Location: Chr: 10 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 17 figures from 3 publications
Directly Submitted Expression Data: 5 figures (9 images) from Thisse et al., 2001 [cb965]
  5 figures (8 images) from Thisse et al., 2004 [IMAGE:7150932]
  6 figures (7 images) from Thisse et al., 2004 [IMAGE:7152872]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu745 Point Mutation Unknown Premature Stop ENU
sa61 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6136 Point Mutation Unknown Premature Stop ENU
    sa9511 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12033 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21628 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27530 Point Mutation Unknown Premature Stop ENU
    sa34805 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf134 Point Mutation Unknown Unknown
    Targeting reagents:
    PHENOTYPE
    Data: 59 figures from 22 publications
    Observed in:
    DISEASE ASSOCIATED WITH apc HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    colorectal cancer Colorectal cancer, somatic 114500
    familial adenomatous polyposis Adenomatous polyposis coli 175100
    Brain tumor-polyposis syndrome 2 175100
    Gardner syndrome 175100
    hepatocellular carcinoma Hepatoblastoma, somatic 114550
    stomach cancer Gastric cancer, somatic 613659
    Adenoma, periampullary, somatic
    Desmoid disease, hereditary 135290
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process liver development (more)
    Cellular Component beta-catenin destruction complex (more)
    Molecular Function beta-catenin binding (more)
    GO Terms (all 52)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000225 (1)
  • InterPro:IPR009223 (1)
  • InterPro:IPR009224 (1)
  • InterPro:IPR009232 (1)
  • InterPro:IPR009234 (1)
  • InterPro:IPR009240 (1)
  • InterPro:IPR011989 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR026818 (1)
  • InterPro:IPR026831 (1)
  • InterPro:IPR026836 (1)
  • InterPro:IPR032038 (1)
  • InterPro:IPR036149 (1)
  • PROSITE:PS50176 (1)
  • Pfam:PF00514 (1)
  • Pfam:PF05923 (1)
  • Pfam:PF05924 (1)
  • Pfam:PF05937 (1)
  • Pfam:PF05956 (1)
  • Pfam:PF05972 (1)
  • Pfam:PF16689 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA apc-001 (1) 9187
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM apc No data available
    MARKER RELATIONSHIPS
    apcContained in: [BAC] CH73-238M11 (1) (order this)
    [Fosmid] CH1073-190G7 (1) (order this)
    apcEncodes: [EST] cb965 (1) (order this), IMAGE:7150932 (1) (order this), IMAGE:7152872 (1) (order this)
    [STS] zfish44906-1822h03.q1k
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001143840 (1) 9214bp
    Genomic GenBank:CU861476 (1) 86052bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IWH7 (1) 2754aa
    Sequence Clusters UniGene:160758 (1)
    Sequence Information (all 22)
    OTHER apc GENE PAGES
  • Alliance (1)
  • Gene:386762 (1)
  • VEGA:OTTDARG00000035536 (1)
  • Ensembl(GRCz11):ENSDARG00000058868 (1)
  • ORTHOLOGY for apc (Chr: 10)
    CITATIONS (75)