ZFIN ID: ZDB-GENE-031112-7
Gene Name: APC regulator of WNT signaling pathway
Gene Symbol: apc    Nomenclature History

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Previous Names: cb965 (1), im:7150932, im:7152872

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have beta-catenin binding activity; microtubule binding activity; and protein kinase regulator activity. Involved in several processes, including animal organ development; chordate embryonic development; and embryonic pectoral fin morphogenesis. Predicted to localize to several cellular components, including the beta-catenin destruction complex; centrosome; and lateral plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Is expressed in hypochord; nervous system; neural tube; and trigeminal placode. Orthologous to human APC (APC regulator of WNT signaling pathway).
Genome Resources: Alliance (1),  Gene:386762 (1),  Ensembl(GRCz11):ENSDARG00000058868 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu745 Point Mutation Unknown Premature Stop ENU
ihb345 Small Deletion Exon 14 Unknown CRISPR
ihb346 Small Deletion Exon 14 Unknown CRISPR
ihb347 Small Deletion Exon 15 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa61 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6136 Point Mutation Unknown Premature Stop ENU
    sa9511 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12033 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21628 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27530 Point Mutation Unknown Premature Stop ENU
    sa34805 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf134 Point Mutation Unknown Premature Stop
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-apc 1
    CRISPR2-apc 1
    MO1-apc N/A 8
    MO2-apc N/A 1
    MO3-apc N/A 1
    PHENOTYPE
    Data: 59 figures from 22 publications
    Observed in:
    DISEASE ASSOCIATED WITH apc HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    familial adenomatous polyposis 1 Alliance Adenomatous polyposis coli 175100
    Brain tumor-polyposis syndrome 2 175100
    Gardner syndrome 175100
    hepatocellular carcinoma Alliance Hepatoblastoma, somatic 114550
    hereditary desmoid disease Alliance Desmoid disease, hereditary 135290
    stomach cancer Alliance Gastric cancer, somatic 613659
    Adenoma, periampullary, somatic
    DISEASE ASSOCIATED WITH apc VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process liver development (more)
    Cellular Component beta-catenin destruction complex (more)
    Molecular Function beta-catenin binding (more)
    GO Terms (all 52)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Repeat IPR000225 Armadillo
    Repeat IPR009223 Adenomatous polyposis coli protein repeat
    Repeat IPR009224 SAMP
    Domain IPR009232 EB-1 binding
    Domain IPR009234 Adenomatous polyposis coli protein basic domain
    Repeat IPR009240 Adenomatous polyposis coli protein, 15 residue repeat
    Homologous_superfamily IPR011989 Armadillo-like helical
    Homologous_superfamily IPR016024 Armadillo-type fold
    Family IPR026818 Adenomatous polyposis coli (APC) family
    Homologous_superfamily IPR026831 Adenomatous polyposis coli protein
    Family IPR026836 Adenomatous polyposis coli
    Domain IPR032038 Adenomatous polyposis coli, N-terminal dimerisation domain
    Homologous_superfamily IPR036149 APC, N-terminal coiled-coil domain superfamily
    Repeat IPR041257 Adenomatous polyposis coli (APC) repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apc-201 (1)    Ensembl 9187
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apc No data available
    MARKER RELATIONSHIPS
    apc Contained in: [BAC] CH73-238M11 (1)
    [Fosmid] CH1073-190G7 (1)
    apc Encodes: [EST] cb965 (1) (order this), IMAGE:7150932 (1), IMAGE:7152872 (1)
    [STS] zfish44906-1822h03.q1k
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001143840 (1) 9214 bp
    Genomic GenBank:CU861476 (1) 86052 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IWH7 (1) 2754 aa
    Sequence Clusters UniGene:160758 (1)
    Sequence Information (all 22)
    ORTHOLOGY for apc ( Chr: 10 )
    CITATIONS (84)