Gene

apc

ID
ZDB-GENE-031112-7
Name
APC regulator of WNT signaling pathway
Symbol
apc Nomenclature History
Previous Names
  • cb965 (1)
  • im:7150932
  • im:7152872
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have beta-catenin binding activity; microtubule binding activity; and protein kinase regulator activity. Involved in several processes, including animal organ development; chordate embryonic development; and embryonic pectoral fin morphogenesis. Predicted to localize to several cellular components, including beta-catenin destruction complex; centrosome; and lateral plasma membrane. Is expressed in hypochord; nervous system; neural tube; and trigeminal placode. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; hereditary desmoid disease; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
19 figures from 5 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
61 figures from 24 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apc Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance Colorectal cancer, somatic 114500
familial adenomatous polyposis 1 Alliance Adenoma, periampullary, somatic 175100
familial adenomatous polyposis 1 Alliance Adenomatous polyposis coli 175100
familial adenomatous polyposis 1 Alliance Brain tumor-polyposis syndrome 2 175100
familial adenomatous polyposis 1 Alliance Gardner syndrome 175100
hepatocellular carcinoma Alliance Hepatoblastoma, somatic 114550
hereditary desmoid disease Alliance Desmoid disease, hereditary 135290
stomach cancer Alliance Gastric cancer, somatic 613659
Gastric adenocarcinoma and proximal polyposis of the stomach 619182
Associated With apc Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009232 EB-1 binding
Domain IPR009234 Adenomatous polyposis coli protein basic domain
Domain IPR032038 Adenomatous polyposis coli, N-terminal dimerisation domain
Family IPR026818 Adenomatous polyposis coli (APC) family
Family IPR026836 Adenomatous polyposis coli
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR026831 Adenomatous polyposis coli protein
Homologous_superfamily IPR036149 APC, N-terminal coiled-coil domain superfamily
Repeat IPR000225 Armadillo
Repeat IPR009223 Adenomatous polyposis coli protein repeat
Repeat IPR009224 SAMP
Repeat IPR009240 Adenomatous polyposis coli protein, 15 residue repeat
Repeat IPR041257 Adenomatous polyposis coli (APC) repeat
Domain Details Per Protein
Protein Length Adenomatous polyposis coli Adenomatous polyposis coli (APC) family Adenomatous polyposis coli (APC) repeat Adenomatous polyposis coli, N-terminal dimerisation domain Adenomatous polyposis coli protein Adenomatous polyposis coli protein, 15 residue repeat Adenomatous polyposis coli protein basic domain Adenomatous polyposis coli protein repeat APC, N-terminal coiled-coil domain superfamily Armadillo Armadillo-like helical Armadillo-type fold EB-1 binding SAMP
UniProtKB:A0A0R4IWH7 2754
UniProtKB:F8W4Z3 2745
UniProtKB:Q58EM1 582
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations