Gene

hs6st2

ID
ZDB-GENE-030909-14
Name
heparan sulfate 6-O-sulfotransferase 2
Symbol
hs6st2 Nomenclature History
Previous Names
  • hs6st (1)
  • fb80f12
  • wu:fb80f12 (1)
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Enables heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Acts upstream of or within branching involved in blood vessel morphogenesis and embryonic eye morphogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including immature eye; nervous system; neural keel; somite; and tail bud. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome. Orthologous to human HS6ST2 (heparan sulfate 6-O-sulfotransferase 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hs6st2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Paganini-Miozzo syndrome Alliance ?Paganini-Miozzo syndrome 301025
Associated With hs6st2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR005331 Sulfotransferase
Family IPR010635 Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase P-loop containing nucleoside triphosphate hydrolase Sulfotransferase
UniProtKB:Q800H9 468
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations