| ZFIN ID: ZDB-GENE-030902-4 |
| Gene Name: | adenosine deaminase 2a | |||||||||||||
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| Gene Symbol: | ada2a Nomenclature History |
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Attributions
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| Previous Names: | ADA2-1 (1), cecr1, cecr1a, fj65e02, wu:fj65e02 (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 25 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have several functions, including adenosine deaminase activity; proteoglycan binding activity; and zinc ion binding activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to localize to extracellular space. Is expressed in several structures, including cardiovascular system; gill; kidney; liver; and notochord. Human ortholog(s) of this gene implicated in Sneddon syndrome. Orthologous to human ADA2 (adenosine deaminase 2). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:373884 (1), Ensembl(GRCz11):ENSDARG00000051746 (2) | |||||||||||||
| All Expression Data: | 6 figures from 6 publications |
| Directly Submitted Expression Data: | 1 figure (1 image) from Thisse et al., 2004 [MGC:55247] |
| Wild-type Stages, Structures: | Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult) |
| High Throughput Expression: | GEO (1) , Expression Atlas (1) |
MUTATIONS AND SEQUENCE TARGETING REAGENTS
| Allele | Type | Localization | Consequence | Mutagen | Suppliers |
|---|---|---|---|---|---|
| la023164Tg | Transgenic Insertion | Unknown | Unknown | DNA |
|
| sa38038 | Point Mutation | Unknown | Splice Site | ENU |
|
| sa44262 | Point Mutation | Unknown | Premature Stop | ENU |
|
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Sneddon syndrome | Alliance | ?Sneddon syndrome | 182410 |
| Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome | 615688 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | adenosine catabolic process (more) |
| Cellular Component | extracellular space (more) |
| Molecular Function | adenosine deaminase activity (more) |
| Type | Name | Length (nt) | Analysis | |
|---|---|---|---|---|
| mRNA |
ada2a-201
(1)
|
2484 |
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|
| Browsers: UCSC, NCBI, Ensembl, ZFIN |
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM ada2a
No data available
MARKER RELATIONSHIPS
| ada2a Contained in: | [BAC] CH211-276C7 (1) |
| ada2a Encodes: |
[EST]
fj65e02 (1)
[cDNA] MGC:55247 (1) |
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_001033717 (1) | 2505 nt |
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| Genomic | GenBank:BX004976 (1) | 151137 nt | |
| Polypeptide | UniProtKB:F1R9S0 (1) | 503 aa |
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ORTHOLOGY for ada2a (
Chr:
25
)
CITATIONS (44)