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ZIRC
ZFIN ID: ZDB-GENE-030902-4
Gene Name: adenosine deaminase 2a
Gene Symbol: ada2a    Nomenclature History

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Previous Names: ADA2-1 (1), cecr1, cecr1a, fj65e02, wu:fj65e02 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have several functions, including adenosine deaminase activity; signaling receptor binding activity; and zinc ion binding activity. Predicted to be involved in adenosine catabolic process and inosine biosynthetic process. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in Sneddon syndrome. Is expressed in several structures, including cardiovascular system; gill; kidney; liver; and notochord. Orthologous to human ADA2 (adenosine deaminase 2).
Genome Resources: Alliance (1),  Gene:373884 (1),  Ensembl(GRCz11):ENSDARG00000051746 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 6 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55247]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023164Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38038 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44262 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ada2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Sneddon syndrome Alliance ?Sneddon syndrome 182410
    Vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome 615688
    DISEASE ASSOCIATED WITH ada2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenosine catabolic process (more)
    Cellular Component extracellular space (more)
    Molecular Function adenosine deaminase activity (more)
    GO Terms (all 11)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ada2a-201 (1)    Ensembl 2484
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ada2a No data available
    MARKER RELATIONSHIPS
    ada2a Contained in: [BAC] CH211-276C7 (1) (order this)
    ada2a Encodes: [EST] fj65e02 (1)
    [cDNA] MGC:55247 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001033717 (1) 2505 bp
    Genomic GenBank:BX004976 (1) 151137 bp
    Select Tool
    Polypeptide UniProtKB:F1R9S0 (1) 503 aa
    Sequence Clusters UniGene:77275 (1)
    Sequence Information (all 14)
    ORTHOLOGY for ada2a ( Chr: 25 )
    CITATIONS (42)