ZFIN ID: ZDB-GENE-030826-5
Gene Name: hematopoietic death receptor
Gene Symbol: hdr    Nomenclature History

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Previous Names: zgc:103531, ZH-DR

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process. Localizes to plasma membrane. Is expressed in axis; hematopoietic system; mesoderm; and notochord. Human ortholog(s) of this gene implicated in cervical cancer; head and neck squamous cell carcinoma; hematologic cancer (multiple); and urinary system cancer (multiple). Orthologous to several human genes including TNFRSF10A (TNF receptor superfamily member 10a) and TNFRSF10B (TNF receptor superfamily member 10b).
Genome Resources: Alliance (1),  Gene:373093 (1),  Ensembl(GRCz11):ENSDARG00000004392 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6979 Point Mutation Unknown Splice Site ENU
sa38475 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hdr N/A 1
    MO2-hdr N/A 2
    MO3-hdr N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hdr HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hdr VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of apoptotic process (more)
    Cellular Component plasma membrane (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hdr-201 (1)    Ensembl 1647
    hdr-202 (1)    Ensembl 1441
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hdr No data available
    MARKER RELATIONSHIPS
    hdr Contained in: [BAC] DKEYP-38H2 (1)
    hdr Encodes: [EST] eu245 (1)
    [cDNA] MGC:103531 (1), MGC:192032 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_194391 (1) 1451 nt
    Genomic GenBank:BX323062 (1) 199133 nt
    Select Tool
    Polypeptide UniProtKB:F1QD95 (1) 418 aa
    Sequence Information (all 22)
    ORTHOLOGY for hdr ( Chr: 5 )
    CITATIONS (29)