ZFIN ID: ZDB-GENE-030826-34
Gene Name: N-myc downstream regulated 1a
Gene Symbol: ndrg1a    Nomenclature History

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Previous Names: ndrg1, cb775 (1), wu:fb60h02, zgc:63944

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to be involved in signal transduction. Predicted to localize to cytoplasm. Is expressed in several structures, including integument; otic placode; pronephric mesoderm; pronephros; and visual system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4D. Orthologous to human NDRG1 (N-myc downstream regulated 1).
Genome Resources: Alliance (1),  Gene:792085 (1),  Ensembl(GRCz11):ENSDARG00000032849 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9684 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ndrg1a N/A 1
    DISEASE ASSOCIATED WITH ndrg1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 4D Alliance Charcot-Marie-Tooth disease, type 4D 601455
    DISEASE ASSOCIATED WITH ndrg1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mast cell activation (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ndrg1a-201 (1)    Ensembl 2353
    ndrg1a-202 (1)    Ensembl 2301
    ncRNA ndrg1a-003 (1)    Ensembl 849
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-ndrg1a Mouse IHC 1
    Ab2-ndrg1a Mouse IHC 1
    Ab3-ndrg1a Mouse 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ndrg1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(rho:ndrg1a-IRES-mSEGFP-CAAX) rho CAAXGFPIRESndrg1a Danio rerio 1 1
    Tg2(rho:ndrg1a-IRES-mSEGFP-CAAX) rho CAAXGFPIRESndrg1a Danio rerio 1 1
    MARKER RELATIONSHIPS
    ndrg1a Contained in: [BAC] CH211-38F10 (1)
    ndrg1a Encodes: [EST] cb775 (1) (order this), fb60h02
    [cDNA] MGC:63944 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213348 (1) 2353 nt
    Genomic GenBank:CT573122 (1) 111064 nt
    Select Tool
    Polypeptide UniProtKB:Q6A3P5 (1) 392 aa
    Sequence Information (all 42)
    ORTHOLOGY for ndrg1a ( Chr: 19 )
    CITATIONS (37)