ZFIN ID: ZDB-GENE-030819-1
Gene Name: tumor protein p63
Gene Symbol: tp63
Sequence Ontology ID : SO:0000704

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Previous Names: p63 (1), delta-Np63 (1), fc89f04, id:ibd3516 (1), tp73l (1), wu:fc89f04, wu:fk85h07, wu:fk88b02 (1)

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits DNA binding activity; involved in several processes, including central nervous system development, epidermis morphogenesis, and intrinsic apoptotic signaling pathway in response to  ...
GENE EXPRESSION
All Expression Data: 52 figures from 32 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd3516]
  6 figures (13 images) from Thisse et al., 2005 [eu912]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2525 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015877Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la025475Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029208Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la029209Tg Transgenic Insertion Unknown Unknown DNA
    sa12599 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15970 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33878 Point Mutation Unknown Missense, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH tp63 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    ADULT syndrome ADULT syndrome 103285
    ankyloblepharon-ectodermal defects-cleft lip/palate syndrome Hay-Wells syndrome 106260
    ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 Ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 604292
    orofacial cleft 8 Orofacial cleft 8 618149
    Rapp-Hodgkin syndrome Rapp-Hodgkin syndrome 129400
    split hand-foot malformation 4 Split-hand/foot malformation 4 605289
    Limb-mammary syndrome 603543
    DISEASE ASSOCIATED WITH tp63 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 34)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001660 (1)
  • InterPro:IPR002117 (1)
  • InterPro:IPR008967 (1)
  • InterPro:IPR010991 (1)
  • InterPro:IPR011615 (1)
  • InterPro:IPR012346 (1)
  • InterPro:IPR013761 (1)
  • InterPro:IPR032645 (1)
  • InterPro:IPR036674 (1)
  • InterPro:IPR037611 (1)
  • PROSITE:PS00348 (1)
  • Pfam:PF00870 (1)
  • Pfam:PF07647 (1)
  • Pfam:PF07710 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tp63-001 (1) 2959
    tp63-002 (1) 2783
    tp63-003 (1) 2497
    tp63-004 (1) 1731
    tp63-005 (1) 1444
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tp63
    MARKER RELATIONSHIPS
    tp63Contained in: [BAC] CH211-240D20 (order this), DKEY-11H2 (1) (order this), DKEY-13D19 (1) (order this)
    tp63Encodes: [EST] eu912 (1), fc89f04, fk85h07 (1), fk88b02 (1), ibd3516 (1) (order this)
    [cDNA] MGC:92012 (1) (order this), MGC:174146 (1) (order this), MGC:192897 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152986 (1) 3004bp
    Genomic GenBank:BX004878 (1) 254657bp Blast at MegaBLAST
    Polypeptide UniProtKB:E9QG65 (1) 632aa
    Sequence Clusters UniGene:32588 (1)
    Sequence Information (all 55)
    OTHER tp63 GENE PAGES
  • Alliance (1)
  • Gene:260407 (1)
  • VEGA:OTTDARG00000019803 (1)
  • ORTHOLOGY for tp63 (Chr: 6)
    CITATIONS (93)