ZFIN ID: ZDB-GENE-030724-5
Gene Name: prickle homolog 1a
Gene Symbol: prickle1a    Nomenclature History

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Previous Names: pk1 (2), pk1a (1), prickle1, fk71b09, wu:fk71b09 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have zinc ion binding activity. Involved in several processes, including animal organ development; gastrulation; and generation of neurons. Is expressed in several structures, including central nervous system; ectoderm; eye; mesoderm; and pharyngeal arch. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 1B. Orthologous to human PRICKLE1 (prickle planar cell polarity protein 1).
Genome Resources: Alliance (1),  Gene:368249 (1),  Ensembl(GRCz11):ENSDARG00000040649 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ch105 Small Deletion Unknown Unknown CRISPR
la023364Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023366Tg Transgenic Insertion Unknown Unknown DNA
    la023369Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023371Tg Transgenic Insertion Unknown Unknown DNA
    sa24579 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-prickle1a 2
    MO1-prickle1a N/A 16
    MO2-prickle1a N/A 4
    MO3-prickle1a N/A 1
    MO4-prickle1a N/A 1
    MO5-prickle1a N/A 1
    DISEASE ASSOCIATED WITH prickle1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    progressive myoclonus epilepsy 1B Alliance Epilepsy, progressive myoclonic 1B 612437
    DISEASE ASSOCIATED WITH prickle1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell migration involved in gastrulation (more)
    Molecular Function protein binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prickle1a-201 (1)    Ensembl 5108
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-prickle1a polyclonal IgG Rabbit WB AnaSpec
    2
    CONSTRUCTS WITH SEQUENCES FROM prickle1a No data available
    MARKER RELATIONSHIPS
    prickle1a Contained in: [Fosmid] ZFOS-1598G7 (1)
    prickle1a Encodes: [EST] eu2428 (1), fk71b09 (1)
    [cDNA] MGC:193658 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_183342 (1) 2698 nt
    Genomic GenBank:CU929262 (1) 45837 nt
    Select Tool
    Polypeptide UniProtKB:B3DGT8 (1) 793 aa
    Sequence Information (all 21)
    ORTHOLOGY for prickle1a ( Chr: 25 )
    CITATIONS (60)