ZFIN ID: ZDB-GENE-030722-9
Gene Name: glyoxalase 1
Gene Symbol: glo1    Nomenclature History

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Previous Names: cb554 (1), wu:fb82g09, zgc:66035

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have lactoylglutathione lyase activity and metal ion binding activity. Is expressed in several structures, including alar plate midbrain region; digestive system; eye; midbrain; and segmental plate. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I).
Genome Resources: Alliance (1),  Gene:368213 (1),  Ensembl(GRCz11):ENSDARG00000068978 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 3 publications
Directly Submitted Expression Data: 5 figures (10 images) from Thisse et al., 2001 [cb554]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35581 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf3029 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-glo1 1
    MO1-glo1 N/A 2
    MO2-glo1 N/A 2
    DISEASE ASSOCIATED WITH glo1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH glo1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Molecular Function lactoylglutathione lyase activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA glo1-201 (1)    Ensembl 1523
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-glo1 monoclonal IgG2b Rat WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM glo1 No data available
    MARKER RELATIONSHIPS
    glo1 Contained in: [BAC] DKEYP-2E4 (1)
    glo1 Encodes: [EST] cb554 (1) (order this), fb82g09 (1)
    [cDNA] MGC:66035 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213151 (1) 1480 nt
    Genomic GenBank:CR786566 (1) 131584 nt
    Select Tool
    Polypeptide UniProtKB:Q6P696 (1) 180 aa
    Sequence Information (all 12)
    ORTHOLOGY for glo1 ( Chr: 13 )
    CITATIONS (28)