ZFIN ID: ZDB-GENE-030616-81
Gene Name: nuclear receptor corepressor 2
Gene Symbol: ncor2    Nomenclature History

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Previous Names: gb:be017685, si:bz71m17.2, smrt (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have several functions, including histone deacetylase binding activity; nuclear hormone receptor binding activity; and transcription corepressor activity. Involved in hematopoietic stem cell differentiation; macrophage differentiation; and neutrophil differentiation. Predicted to localize to histone deacetylase complex; nuclear chromatin; and transcription repressor complex. Is expressed in several structures, including anterior axial hypoblast; cardiovascular system; central nervous system; eye; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR2 (nuclear receptor corepressor 2).
Genome Resources: Alliance (1),  Gene:561503 (1),  Ensembl(GRCz11):ENSDARG00000000966 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029488Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1781 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7154 Point Mutation Unknown Premature Stop ENU
    sa11868 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12530 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13457 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14103 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15101 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15996 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21361 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21362 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34466 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34467 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34468 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38706 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41278 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41279 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ncor2
    1
    MO1-ncor2 N/A 3
    MO2-ncor2 N/A 1
    MO3-ncor2 N/A 1
    MO4-ncor2 N/A 1
    DISEASE ASSOCIATED WITH ncor2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ncor2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hematopoietic stem cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ncor2-201 (1)    Ensembl 6325
    ncor2-204 (1)    Ensembl 6295
    ncRNA ncor2-003 (1)    Ensembl 539
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ncor2 No data available
    MARKER RELATIONSHIPS
    ncor2 Contained in: [BAC] RP71-71M17 (1)
    ncor2 Encodes: [EST] be017685 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001007032 (1)
    Genomic GenBank:AL590153 (1) 133947 nt
    Select Tool
    Polypeptide UniProtKB:E7FF48 (1) 2315 aa
    Sequence Information (all 36)
    ORTHOLOGY for ncor2 ( Chr: 8 )
    CITATIONS (44)