ZFIN ID: ZDB-GENE-030616-630
Gene Name: FKBP prolyl isomerase 5
Gene Symbol: fkbp5    Nomenclature History

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Previous Names: si:zc263a23.8, wu:fc31g11, wu:fl87b03, zgc:64082

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in chaperone-mediated protein folding and protein peptidyl-prolyl isomerization. Predicted to localize to cytoplasm. Is expressed in gut; head; and regenerating fin. Human ortholog(s) of this gene implicated in major depressive disorder. Orthologous to human FKBP5 (FKBP prolyl isomerase 5).
Genome Resources: Alliance (1),  Gene:368924 (1),  Ensembl(GRCz11):ENSDARG00000028396 (2)
GENE EXPRESSION
All Expression Data: 13 figures from 10 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:64082]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12885 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15952 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH fkbp5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    endogenous depression Alliance {Major depressive disorder and accelerated response to antidepressant drug treatment} 608516
    DISEASE ASSOCIATED WITH fkbp5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein peptidyl-prolyl isomerization (more)
    Cellular Component cytoplasm (more)
    Molecular Function FK506 binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fkbp5-201 (1)    Ensembl 2613
    ncRNA fkbp5-002 (1)    Ensembl 917
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fkbp5 No data available
    MARKER RELATIONSHIPS
    fkbp5 Contained in: [BAC] CH211-263A23 (1)
    fkbp5 Encodes: [EST] fc31g11 (1), fl87b03 (1)
    [cDNA] MGC:64082 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_213149 (1) 2613 nt
    Genomic GenBank:AL732567 (1) 152840 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RWP8 (1) 470 aa
    Sequence Information (all 19)
    ORTHOLOGY for fkbp5 ( Chr: 6 )
    CITATIONS (61)