ZFIN ID: ZDB-GENE-030616-541
Gene Name: karyopherin alpha 3 (importin alpha 4)
Gene Symbol: kpna3    Nomenclature History

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Previous Name: si:dz79f24.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have nuclear import signal receptor activity. Predicted to be involved in protein import into nucleus. Predicted to localize to the cytoplasm and nucleus. Orthologous to human KPNA3 (karyopherin subunit alpha 3).
Genome Resources: Alliance (1),  Gene:368640 (1),  Ensembl(GRCz11):ENSDARG00000052641 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:63818]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9826 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24854 Point Mutation Unknown Splice Site ENU
    zko910a Indel Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kpna3 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kpna3 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH kpna3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein import into nucleus (more)
    Cellular Component cytoplasm (more)
    Molecular Function nuclear import signal receptor activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR002652 Importin-alpha, importin-beta-binding domain
    Family IPR024931 Importin subunit alpha
    Homologous_superfamily IPR011989 Armadillo-like helical
    Homologous_superfamily IPR016024 Armadillo-type fold
    Homologous_superfamily IPR036975 Importin-alpha, importin-beta-binding domain superfamily
    Repeat IPR000225 Armadillo
    Repeat IPR032413 Atypical Arm repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kpna3-201 (1)    Ensembl 3998
    ottdart00000001842 (1) 1816
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kpna3 No data available
    MARKER RELATIONSHIPS
    kpna3 Contained in: [BAC] DKEY-7A20 (1) (order this)
    [PAC] BUSM1-79F24 (1)
    kpna3 Encodes: [cDNA] MGC:63818 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201320 (1) 2236 nt
    Genomic GenBank:BX294379 (1) 214290 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q8JFT7 (1) 520 aa
    Sequence Information (all 18)
    ORTHOLOGY for kpna3 ( Chr: 1 )
    CITATIONS (26)