Gene
mcf2a
- ID
- ZDB-GENE-030616-52
- Name
- MCF.2 cell line derived transforming sequence a
- Symbol
- mcf2a Nomenclature History
- Previous Names
-
- mcf2
- si:bz1l9.2
- si:rp71-1l9.2
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in dendrite development. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm. Orthologous to human MCF2 (MCF.2 cell line derived transforming sequence).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la027539Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11503 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa28332 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35715 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | CRAL-TRIO lipid binding domain | CRAL-TRIO lipid binding domain superfamily | Dbl homology (DH) domain superfamily | DBS, PH domain | DBS, SH3 domain | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | PH-like domain superfamily | Pleckstrin homology domain | Rho GTPase-activating Guanine Nucleotide Exchange Factors | SH3 domain | SH3-like domain superfamily | SOS1/NGEF-like, PH domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BKK0
|
1110 | ||||||||||||
|
UniProtKB:A0A8M9PUG5
|
1111 | ||||||||||||
|
UniProtKB:A0A8M3B0F9
|
1082 | ||||||||||||
|
UniProtKB:F1Q4X6
|
1111 | ||||||||||||
|
UniProtKB:A0A8M3AI08
|
806 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-79C4 | ZFIN Curated Data | |
| Contained in | BAC | RP71-1L9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005173226 (1) | 5141 nt | ||
| Genomic | GenBank:AL627263 (1) | 174521 nt | ||
| Polypeptide | UniProtKB:A0A8M9PUG5 (1) | 1111 aa |
- Mo, C., Li, W., Jia, K., Liu, W., Yi, M. (2021) Proper Balance of Small GTPase rab10 Is Critical for PGC Migration in Zebrafish. International Journal of Molecular Sciences. 22(21):
- Hawkey-Noble, A., Umali, J., Fowler, G., French, C.R. (2020) Expression of three P4- phospholipid Flippases-atp11a, atp11b, and atp11c in zebrafish (Danio rerio). Gene expression patterns : GEP. 36:119115
- Shi, W.J., Zhao, J.L., Jiang, Y.X., Huang, G.Y., Liu, Y.S., Zhang, J.N., Ying, G.G. (2017) TRANSCRIPTIONAL AND HISTOLOGICAL ALTERATIONS IN GONAD OF ADULT ZEBRAFISH AFTER EXPOSURE TO THE SYNTHETIC PROGESTIN NORGESTREL. Environmental toxicology and chemistry. 36(12):3267-3276
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Deng, C., Chen, H., Yang, N., Feng, Y., Hsueh, A.J. (2015) Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling. The Journal of biological chemistry. 290(30):18261-8
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Mitchell, R.E., Huitema, L.F., Skinner, R.H., Brunt, L.H., Severn, C., Schulte-Merker, S., and Hammond, C.L. (2013) New tools for studying osteoarthritis genetics in zebrafish. Osteoarthritis and Cartilage. 21(2):269-278
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Navratilova, P., Fredman, D., Hawkins, T.A., Turner, K., Lenhard, B., and Becker, T.S. (2009) Systematic human/zebrafish comparative identification of cis-regulatory activity around vertebrate developmental transcription factor genes. Developmental Biology. 327(2):526-540
- Keller, M.J., and Chitnis, A.B. (2007) Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio. Development genes and evolution. 217(7):541-547
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