ZFIN ID: ZDB-GENE-030616-358
Gene Name: coiled-coil domain containing 65
Gene Symbol: ccdc65    Nomenclature History

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Previous Names: si:busm1-202l16.3 (1), si:dz202l16.3, zgc:92302

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Involved in regulation of cilium movement. Predicted to localize to axoneme. Is expressed in pronephric duct and spinal cord. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 27. Orthologous to human CCDC65 (coiled-coil domain containing 65).
Genome Resources: Alliance (1),  Gene:368824 (1),  Ensembl(GRCz11):ENSDARG00000032005 (1)
Note: novel protein similar to human NYD-SP28
GENE EXPRESSION
All Expression Data: Fig. 1 from Austin-Tse et al., 2013
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6066 Point Mutation Unknown Premature Stop ENU
sa20626 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ccdc65 N/A 1
    MO2-ccdc65 N/A 1
    DISEASE ASSOCIATED WITH ccdc65 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary ciliary dyskinesia 27 Alliance Ciliary dyskinesia, primary, 27 615504
    DISEASE ASSOCIATED WITH ccdc65 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of cilium movement (more)
    Cellular Component axonemal dynein complex (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ccdc65-201 (1)    Ensembl 1531
    ottdart00000001492 (1) 1344
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ccdc65 No data available
    MARKER RELATIONSHIPS
    ccdc65 Contained in: [BAC] CH211-241A17 (1)
    [PAC] BUSM1-202L16 (1)
    ccdc65 Encodes: [cDNA] MGC:92302 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002603 (1) 1571 nt
    Genomic GenBank:AL953886 (1) 154152 nt
    Select Tool
    Polypeptide UniProtKB:Q6DHI2 (1) 492 aa
    Sequence Information (all 16)
    ORTHOLOGY for ccdc65 ( Chr: 6 )
    CITATIONS (23)