ZFIN ID: ZDB-GENE-030326-4
Gene Name: heat shock protein, alpha-crystallin-related, 1
Gene Symbol: hspb1    Nomenclature History

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Previous Names: hsp27 (1), cb153 (1), cb660 (1), id:ibd2821, sb:cb660, zgc:103437

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Involved in regulation of myofibril size; response to arsenic-containing substance; and response to heat. Localizes to cytoplasm and nucleus. Is expressed in several structures, including mesoderm; musculature system; nervous system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2F; distal hereditary motor neuropathy type 2B; pancreatic cancer; and sarcoma. Orthologous to human HSPB1 (heat shock protein family B (small) member 1).
Genome Resources: Alliance (1),  Gene:368243 (1),  Ensembl(GRCz11):ENSDARG00000041065 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-hspb1
2
MO1-hspb1 N/A 3
DISEASE ASSOCIATED WITH hspb1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease axonal type 2F Alliance Charcot-Marie-Tooth disease, axonal, type 2F 606595
distal hereditary motor neuropathy type 2B Alliance Neuronopathy, distal hereditary motor, type IIB 608634
DISEASE ASSOCIATED WITH hspb1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to arsenic-containing substance (more)
Cellular Component cytoplasm (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hspb1-201 (1)    Ensembl 1052
hspb1-203 (1)    Ensembl 498
ncRNA hspb1-002 (1)    Ensembl 745
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-hspb1 polyclonal IHC, WB 6
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hspb1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(hspb1:EGFP) hspb1 EGFP Danio rerio 1 3
Tg(lyz:hspb1,mCherry) lyz hspb1mCherry Danio rerio 1 2
Tg2(hspb1:EGFP) hspb1 EGFP Danio rerio 1 3
MARKER RELATIONSHIPS
hspb1 Contained in: [Fosmid] ZFOS-631D6 (1)
hspb1 Contains: [STS] chunp30328
hspb1 Encodes: [EST] cb153 (1) (order this), cb660 (1) (order this), ibd2821
[cDNA] MGC:103437 (1), MGC:114088 (1), MGC:192174 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001008615 (1) 914 nt
Genomic GenBank:FP017189 (1) 33555 nt
Select Tool
Polypeptide UniProtKB:A4VAK4 (1) 199 aa
Sequence Information (all 37)
ORTHOLOGY for hspb1 ( Chr: 5 )
CITATIONS (50)