ZFIN ID: ZDB-GENE-030326-4
Gene Name: heat shock protein, alpha-crystallin-related, 1
Gene Symbol: hspb1
Previous Names: hsp27 (1), cb153 (1), cb660 (1), id:ibd2821, sb:cb660, zgc:103437
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 39 figures from 11 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb660]
  2 figures (2 images) from Kudoh et al., 2001 [ibd2821]
  6 figures (38 images) from Thisse et al., 2001 [cb153]
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Adult (90d-730d, breeding adult)
  adaxial cell, adductor mandibulae, atrioventricular canal, blastoderm (all 56) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-hspb1 (1)
PHENOTYPE
Data: 3 figures from Middleton et al., 2013
Observed in: adductor mandibulae muscle cell, adductor mandibulae regulation of myofibril size, adductor mandibulae, interhyoideus muscle cell (all 8) expand
DISEASE ASSOCIATED WITH hspb1 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Charcot-Marie-Tooth disease type 2 Charcot-Marie-Tooth disease, axonal, type 2F 606595
distal hereditary motor neuropathy Neuropathy, distal hereditary motor, type IIB 608634
GENE ONTOLOGY
Ontology GO Term
Biological Process response to arsenic-containing substance (more)
Cellular Component cytoplasm (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001436 (1)
  • InterPro:IPR002068 (1)
  • InterPro:IPR008978 (1)
  • PROSITE:PS01031 (1)
  • Pfam:PF00011 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hspb1-001 (1) 1052
    ncRNA hspb1-002 (1) 745
    mRNA hspb1-003 (1) 498
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-hspb1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hspb1
    Tg(hspb1:EGFP), Tg(lyz:hspb1,mCherry), Tg2(hspb1:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    hspb1 Contained in: [Fosmid] ZFOS-631D6 (1)
    hspb1 Contains: [STS] chunp30328
    hspb1 Encodes: [EST] cb153 (1) (order this), cb660 (1) (order this), ibd2821 (order this)
    [cDNA] MGC:103437 (1) (order this), MGC:114088 (1) (order this), MGC:192174 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001008615 (1) 957 bp
    Genomic GenBank:FP017189 (1) 33555 bp
    Select Tool
    Polypeptide UniProtKB:A4VAK4 (1) 199 aa
    Sequence Clusters UniGene:32244 (1)
    Sequence Information (all 37)
    OTHER hspb1 GENE PAGES
  • Gene:368243 (1)
  • VEGA:OTTDARG00000035270 (1)
  • Ensembl(Zv9):ENSDARG00000041065 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish hspb1 5  
    Human HSPB1 7 (7q11.23)
  • OMIM:602195
  • Gene:3315
  • Orthology Details
    CITATIONS (31)