Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-030326-4
Gene Name: heat shock protein, alpha-crystallin-related, 1
Gene Symbol: hspb1
Previous Names: hsp27 (1), cb153 (1), cb660 (1), id:ibd2821, sb:cb660, zgc:103437
Location: Chr: 5   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 39 figures from 11 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb660]
  2 figures (2 images) from Kudoh et al., 2001 [ibd2821]
  6 figures (38 images) from Thisse et al., 2001 [cb153]
Wild-type Stages, Structures: Cleavage:16-cell (1.5h-1.75h) to Adult (90d-730d, breeding adult)
  adaxial cell, adductor mandibulae, atrioventricular canal, blastoderm (all 54) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-hspb1 (1)
PHENOTYPE
Data: 3 figures from Middleton et al., 2013
Observed in: adductor mandibulae muscle cell, adductor mandibulae regulation of myofibril size, adductor mandibulae, medial rectus (all 8) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Charcot-Marie-Tooth disease, axonal, type 2F 606595
Neuropathy, distal hereditary motor, type IIB 608634
GENE ONTOLOGY
Ontology GO Term
Biological Process response to arsenic-containing substance (more)
Cellular Component cytoplasm (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001436 (1)
  • InterPro:IPR002068 (1)
  • InterPro:IPR008978 (1)
  • PROSITE:PS01031 (1)
  • Pfam:PF00011 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hspb1-001 (1) 1052
    ncRNA hspb1-002 (1) 745
    mRNA hspb1-003 (1) 498
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-hspb1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hspb1
    Tg(hspb1:EGFP), Tg(lyz:hspb1,mCherry), Tg2(hspb1:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    hspb1 Contained in: [Fosmid] ZFOS-631D6 (1)
    hspb1 Contains: [STS] chunp30328
    hspb1 Encodes: [EST] cb153 (1) (order this), cb660 (1) (order this), ibd2821 (order this)
    [cDNA] MGC:103437 (1) (order this), MGC:114088 (1) (order this), MGC:192174 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001008615 (1) 957 bp
    Genomic GenBank:FP017189 (1) 33555 bp
    Select Tool
    Polypeptide UniProtKB:A4VAK4 (1) 199 aa
    Sequence Clusters UniGene:32244 (1)
    Sequence Information (all 37)
    OTHER hspb1 GENE PAGES
  • Gene:368243 (1)
  • VEGA:OTTDARG00000035270 (1)
  • Ensembl(Zv9):ENSDARG00000041065 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish hspb1 5  
    Human HSPB1 7 (7q11.23)
  • OMIM:602195
  • Gene:3315
  • Orthology Details
    CITATIONS (32)