ZFIN ID: ZDB-GENE-030318-3
Gene Name: myosin VIb
Gene Symbol: myo6b    Nomenclature History

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Previous Names: sai (1), satellite (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Involved in detection of mechanical stimulus involved in sensory perception and inner ear auditory receptor cell differentiation. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 22; autosomal recessive nonsyndromic deafness 37; ovarian cancer; and sensorineural hearing loss. Is expressed in anterior macula. Orthologous to human MYO6 (myosin VI).
Genome Resources: Alliance (1),  Gene:445472 (1),  Ensembl(GRCz11):ENSDARG00000042141 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 5 publications
Wild-type Stages, Structures: Blastula:256-cell (2.5h-2.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ru920 Point Mutation Exon 5 Premature Stop ENU
sa2929 Point Mutation Unknown Splice Site ENU
sa18082 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42976 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t2460 Point Mutation Unknown Unknown
    tn011 Point Mutation Unknown Unknown
    tn3137 Point Mutation Unknown Unknown
    tn3216 Point Mutation Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-myo6b
    1
    CRISPR2-myo6b
    1
    DISEASE ASSOCIATED WITH myo6b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nonsyndromic deafness 22 Alliance Deafness, autosomal dominant 22 606346
    Deafness, autosomal dominant 22, with hypertrophic cardiomyopathy 606346
    autosomal recessive nonsyndromic deafness 37 Alliance Deafness, autosomal recessive 37 607821
    DISEASE ASSOCIATED WITH myo6b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process detection of mechanical stimulus involved in sensory perception (more)
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001609 Myosin head, motor domain
    Domain IPR004009 Myosin, N-terminal, SH3-like
    Domain IPR032412 Myosin VI, cargo binding domain
    Domain IPR036114 Class VI myosin, motor domain
    Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myo6b-202 (1)    Ensembl 3888
    myo6b-203 (1)    Ensembl 3997
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myo6b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-6.5myo6b:ctbp2l-EGFP) myo6b ctbp2lEGFP Danio rerio 1 7
    Tg(-6.5myo6b:HA-Tgo.Uprt-2A-mCherry) myo6b 2AHAmCherry Danio rerioToxoplasma gondii 1 1
    Tg(-6.5myo6b:nsfa-EGFP) myo6b EGFPnsfa Danio rerio 2 3
    Tg(-6myo6b:ctbp2a-mCherry) myo6b ctbp2amCherry Danio rerio 1 2
    Tg(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    Tg(cryaa:mCherry,myo6b:NLS-Eco.TrpR-GAL4) cryaamyo6b GAL4mCherry Danio rerioEscherichia coli 1 4
    Tg(myo6b:actb1-EGFP) myo6b actb1EGFP Danio rerio 1 15
    Tg(myo6b:atp6v1aa-EGFP,myl7:EGFP) myl7myo6b atp6v1aaEGFP Danio rerio 1 3
    Tg(myo6b:Bongwoori-2A-NLSmCherry) myo6b Bongwoori2AmCherryNLS Danio rerio 1 2
    Tg(myo6b:comta-EGFP) myo6b comtaEGFP Danio rerio 1 1
    Tg(myo6b:comta-emGFP) myo6b comtaemGFP Danio rerio 1 1
    Tg(myo6b:Cr.ChR2-EYFP) myo6b EYFP Chlamydomonas reinhaDanio rerio 1 3
    Tg(myo6b:ctbp2a-mCherry) myo6b ctbp2amCherry Danio rerio 1 2
    Tg(myo6b:ctbp2a-TagRFP) myo6b ctbp2aTagRFP Danio rerio 0 1
    Tg(myo6b:ctbp2l-mCherry) myo6b ctbp2lmCherry Danio rerio 1 3
    Tg(myo6b:D3cpv) myo6b D3cpv Danio rerio 1 4
    Tg(myo6b:EGFP) myo6b EGFP Danio rerio 1 5
    Tg(myo6b:EGFP-bcl2a,myl7:EGFP) myl7myo6b bcl2aEGFP Danio rerio 1 3
    Tg(myo6b:EGFP-lhfpl5a) myo6b EGFPlhfpl5a Danio rerio 1 2
    tg(myo6b:egfp-pa) myo6b EGFPPA Danio rerio 1 1
    Tg(myo6b:emx2-2A-NLS-mCherry) myo6b 2Aemx2mCherryNLS Danio rerio 1 2
    Tg(myo6b:GAL4FF) myo6b GAL4FF Danio rerio 1 1
    Tg(myo6b:GCaMP3) myo6b GCaMP Danio rerio 1 8
    Tg(myo6b:GCaMP6s-CAAX) myo6b CAAXGCaMP Danio rerio 1 5
    Tg(myo6b:GFP-p2A-rpl10a) myo6b 2AGFPHArpl10a Danio rerio 1 3
    tg(myo6b:gria2a-tmie-2a-nls-mcherry) myo6b 2Agria2amCherryNLStmie Danio rerio 1 1
    tg(myo6b:gria2a-tmie-egfp) myo6b EGFPgria2atmie Danio rerio 1 1
    Tg(myo6b:HyPer) myo6b HyPer Danio rerio 1 1
    Tg(myo6b:jRCaMP-CAAX) myo6b CAAXRCaMP Danio rerio 1 2
    tg(myo6b:kdel-crimson) myo6b CrimsonKDEL Danio rerio 1 1
    tg(myo6b:lifeact-tagrfp,cryaa:mcherry) cryaamyo6b LIFEACTmCherryTagRFP Danio rerio 1 1
    Tg(myo6b:map1b-GFP) myo6b GFPmap1b Danio rerio 1 3
    Tg(myo6b:mCherry-CAAX) myo6b mCherry Danio rerio 1 2
    Tg(myo6b:mgat1a-mKate2) myo6b mgat1amKate2 Danio rerio 1 1
    tg(myo6b:mito-dsred1-e5) myo6b DsRedMITO Danio rerio 1 1
    tg(myo6b:mito-eos) myo6b EosMITO Danio rerio 1 1
    Tg(myo6b:MITO-GCaMP3) myo6b GCaMPMITO Danio rerio 1 3
    Tg(myo6b:MITO-RGECO1) myo6b MITORGECO Danio rerio 0 1
    Tg(myo6b:mKate2) myo6b mKate2 Danio rerio 1 1
    Tg(myo6b:Mmu.Tomt-emGFP) myo6b emGFP Danio rerioMus musculus 1 1
    Tg(myo6b:Mmu.Tomt_H183A-emGFP) myo6b emGFP Danio rerioMus musculus 1 1
    tg(myo6b:mrfp-actr10) myo6b actr10mRFP Danio rerio 1 1
    Tg(myo6b:NLS-Eos) myo6b EosNLS Danio rerio 1 1
    Tg(myo6b:pHGFP2) myo6b pHGFP Danio rerio 1 3
    Tg(myo6b:pHGFP2-Hsa.FOLR1) myo6b pHGFP Danio rerioHomo sapiens 1 3
    Tg(myo6b:RexYFP) myo6b RexYFP Danio rerio 0 1
    Tg(myo6b:RFP-vangl2) myo6b RFPvangl2 Danio rerio 1 2
    Tg(myo6b:RGECO1) myo6b RGECO Danio rerio 1 6
    Tg(myo6b:SYPHY) myo6b SYPHY Danio rerio 1 2
    Tg(myo6b:tmc1-EGFP) myo6b EGFPtmc1 Danio rerio 1 2
    Tg(myo6b:tmc2a-GFP-CAAX) myo6b CAAXGFPtmc2a Danio rerio 1 3
    Tg(myo6b:tmc2b-EGFP) myo6b EGFPtmc2b Danio rerio 1 2
    tg(myo6b:tmie-2a-nls-mcherry) myo6b 2AmCherryNLStmie Danio rerio 1 1
    tg(myo6b:tmie-egfp) myo6b EGFPtmie Danio rerio 1 1
    Tg(myo6b:tmie-HA) myo6b HAtmie Danio rerio 1 1
    tg(myo6b:tmie-hsa.cd8a-2a-nls-mcherry) myo6b 2AmCherryNLStmie Danio rerio 1 1
    tg(myo6b:tmie-hsa.cd8a-egfp) myo6b EGFPtmie Danio rerio 1 1
    Tg(myo6b:Tomato) myo6b Tomato Danio rerio 1 1
    Tg(myo6b:tomt-EGFP) myo6b EGFPtomt Danio rerio 1 1
    Tg(myo6b:tomt-emGFP) myo6b emGFPtomt Danio rerio 1 1
    Tg(myo6b:tomt-HA) myo6b HAtomt Danio rerio 1 1
    Tg2(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 2
    tg2(myo6b:egfp) myo6b EGFP Danio rerio 1 1
    Tg3(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    Tg4(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    Tg5(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    Tg6(-6myo6b:pcdh15a-EGFP) myo6b EGFPpcdh15a Danio rerio 1 1
    MARKER RELATIONSHIPS
    myo6b Contained in: [BAC] DKEY-77G5 (1) (order this), DKEY-264C3 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001004110 (1) 3917 nt
    Genomic GenBank:BX571720 (1) 227706 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E7FGA0 (1) 1267 aa
    Sequence Information (all 24)
    ORTHOLOGY for myo6b ( Chr: 17 )
    CITATIONS (63)