Gene

zic2b

ID
ZDB-GENE-030219-92
Name
zic family member 2 (odd-paired homolog, Drosophila) b
Symbol
zic2b Nomenclature History
Previous Names
  • zic2.2 (1)
  • zic2l
  • hm:zeh0655
  • id:ibd5017
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in animal organ development and regulation of retinoic acid receptor signaling pathway. Predicted to localize to nucleus. Is expressed in several structures, including germ ring; immature eye; nervous system; neural keel; and neural plate. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2).
Genome Resources
Note
None
Expression
All Expression Data
16 figures from 11 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from Teslaa et al., 2013
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zic2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
holoprosencephaly 5 Alliance Holoprosencephaly 5 609637
Associated With zic2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013087 Zinc finger C2H2-type
Domain IPR041643 ZIC protein, zinc finger domain
Homologous_superfamily IPR036236 Zinc finger C2H2 superfamily
Domain Details Per Protein
Protein Length ZIC protein, zinc finger domain Zinc finger C2H2 superfamily Zinc finger C2H2-type
UniProtKB:Q9DE40 427
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations