ZFIN ID: ZDB-GENE-030131-9770
Gene Name: angiomotin like 2a
Gene Symbol: amotl2a    Nomenclature History

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Previous Names: amotl2, cb308 (1), sb:cb308, wu:fc41b07, wu:fc64c06

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Involved in several processes, including blood vessel morphogenesis; endothelial cell proliferation; and filopodium assembly. Localizes to cell cortex; cell-cell junction; and polymeric cytoskeletal fiber. Is expressed in several structures, including cardiovascular system; ectoderm; mesoderm; nervous system; and neural plate. Orthologous to human AMOTL2 (angiomotin like 2).
Genome Resources: Alliance (1),  Gene:558920 (1),  Ensembl(GRCz11):ENSDARG00000061923 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fu45 Small Deletion Exon 3 Frameshift, Premature Stop TALEN
fu46 Small Deletion Exon 3 Frameshift, Premature Stop TALEN
sa16774 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18236 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18416 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20712 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20713 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33875 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40700 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44636 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-amotl2a N/A 7
    MO2-amotl2a N/A 1
    TALEN1-amotl2a 1
    DISEASE ASSOCIATED WITH amotl2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH amotl2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin cytoskeleton organization (more)
    Cellular Component cell-cell junction (more)
    Molecular Function protein binding (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA amotl2a-201 (1)    Ensembl 4147
    amotl2a-202 (1)    Ensembl 242
    amotl2a-203 (1)    Ensembl 557
    amotl2a-204 (1)    Ensembl 615
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-amotl2a polyclonal Rabbit IHC 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM amotl2a No data available
    MARKER RELATIONSHIPS
    amotl2a Contained in: [BAC] DKEY-233G13 (1) (order this)
    amotl2a Encodes: [EST] cb308 (1) (order this), fc41b07, fc64c06
    [cDNA] MGC:194605 (1)
    amotl2a Has Artifact: [EST] fc41b02
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001080177 (1) 2434 nt
    Genomic GenBank:CR626940 (1) 59073 nt
    Select Tool
    Polypeptide UniProtKB:A1YB07 (1) 721 aa
    Sequence Information (all 19)
    ORTHOLOGY for amotl2a ( Chr: 6 )
    CITATIONS (32)